Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation.

Genes & Development
Juliane FellerA Gossler

Abstract

To test the significance of cyclic Notch activity for somite formation in mice, we analyzed embryos expressing activated Notch (NICD) throughout the presomitic mesoderm (PSM). Embryos expressing NICD formed up to 18 somites. Expression in the PSM of Hes7, Lfng, and Spry2 was no longer cyclic, whereas Axin2 was expressed dynamically. NICD expression led to caudalization of somites, and loss of Notch activity to their rostralization. Thus, segmentation and anterior-posterior somite patterning can be uncoupled, differential Notch signaling is not required to form segment borders, and Notch is unlikely to be the pacemaker of the segmentation clock.

References

Feb 1, 1993·Genes & Development·D StottB G Herrmann
Apr 17, 1997·Nature·M Hrabĕ de AngelisA Gossler
Oct 6, 1999·Current Opinion in Genetics & Development·O Pourquié
Aug 10, 2000·Nature Genetics·Y TakahashiY Saga
Oct 20, 2001·Genes & Development·Y BesshoR Kageyama
Feb 19, 2003·Nature Genetics·Michael NicolasFreddy Radtke
Mar 15, 2003·Developmental Cell·Alexander AulehlaBernhard G Herrmann
Apr 3, 2003·Genes & Development·Katrin SerthAchim Gossler
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shaolin Shi, Pamela Stanley
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·L Charles MurtaughDouglas A Melton
Jun 1, 2004·Nature Genetics·Hiromi HirataRyoichiro Kageyama
Aug 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Marie-Claire DelfiniOlivier Pourquié
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yukuto YasuhikoYumiko Saga
Nov 11, 2006·Science·Mary-Lee DequéantOlivier Pourquié
Mar 31, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yumiko Saga
Apr 10, 2007·Nature Cell Biology·Andrew MaraScott A Holley
Dec 25, 2007·Nature Cell Biology·Alexander AulehlaOlivier Pourquié

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Citations

Oct 25, 2008·Development Genes and Evolution·Laura Beaster-JonesLinda Z Holland
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Alexander Aulehla, Olivier Pourquié
Jun 3, 2009·Journal of Biology·Julian LewisMaxine Holder
Jul 5, 2012·PLoS Computational Biology·Hendrik B TiedemannMartin Hrabě de Angelis
Nov 19, 2013·PLoS Genetics·Brian DeVealeDerek van der Kooy
Jul 3, 2013·Annual Review of Cell and Developmental Biology·Bertrand Bénazéraf, Olivier Pourquié
Jan 26, 2016·Seminars in Cell & Developmental Biology·Caroline J SheebaIsabel Palmeirim
Oct 15, 2011·Genesis : the Journal of Genetics and Development·Luke T KrebsThomas Gridley
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Ryoichiro KageyamaYukiko Harima
Nov 29, 2011·Genesis : the Journal of Genetics and Development·T Peter Lopez, Chen-Ming Fan
Oct 22, 2011·Developmental Biology·Stephanie GraingerDavid Lohnes
Feb 7, 2012·Seminars in Cell & Developmental Biology·Andrea L PentonNancy B Spinner
Jul 16, 2014·Mechanisms of Development·Benedikt SchwartzPhillip Grote
Jun 30, 2012·Current Opinion in Genetics & Development·Yumiko Saga
Oct 11, 2008·Current Opinion in Cell Biology·Alexander Aulehla, Olivier Pourquié
May 28, 2013·Developmental Biology·Keiko KitajimaChikara Meno
Mar 11, 2009·Developmental Biology·Sarah GibbJ Kim Dale
Oct 23, 2014·Nature Reviews. Molecular Cell Biology·Alexis Hubaud, Olivier Pourquié
Dec 9, 2014·Seminars in Cell & Developmental Biology·Kanu WahiSusan E Cole
Jun 27, 2015·PLoS Genetics·Kristina PreußeMichael Stauber
Aug 11, 2018·ELife·Thomas Jr FrithAnestis Tsakiridis
Oct 9, 2019·BMC Developmental Biology·Shweta VarshneyPamela Stanley
Jan 19, 2021·Development, Growth & Differentiation·Margarete Diaz-Cuadros, Olivier Pourquie
Jul 16, 2019·Developmental Biology·Olivier F Venzin, Andrew C Oates
May 1, 2021·International Journal of Molecular Sciences·Alessandra Guasto, Valérie Cormier-Daire
Jun 1, 2021·Interface Focus·Erik Clark
Dec 14, 2021·Frontiers in Cell and Developmental Biology·Marta Linde-Medina, Theodoor H Smit

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