PMID: 9430244Jan 16, 1998Paper

Nondestructive determination of iliac crest cancellous bone strength by pQCT

Bone
E N EbbesenL Mosekilde

Abstract

The close relationship between apparent bone density and compressive strength is well established. In clinical situations, histomorphometry and determination of the compressive strength on bone biopsies are destructive methods and require two separate biopsies from each patient. The aim of this study was to evaluate whether volumetric bone density measured by peripheral quantitative computed tomography (pQCT) could be used as a nondestructive method for estimating trabecular bone strength of iliac crest bone biopsies, thereby allowing the same biopsy to be used for subsequent histomorphometry. Materials consisted of trabecular bone samples prepared from unilateral transiliac crest bone samples obtained at autopsy [total 95 specimens; 41 females (21-90 years) and 54 males (23-87 years)]. From these, the apparent density of the cancellous bone was evaluated by pQCT in a 1-mm-thick slice in the middle of the biopsy and also by ash density measurement. Bone strength was measured by compression test. A strong power relationship was found between density measured by pQCT and compressive strength (r = 0.93, p < 0.00001). Likewise, there was a strong power relationship between ash density and compressive strength (r = 0.97, p < 0.00001...Continue Reading

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Citations

Oct 30, 2008·European Radiology·Yi-Xiang J WangAnil T Ahuja
Jun 24, 2004·Journal of Biomechanics·Chamith S RajapakseGemunu H Gunaratne
Jul 29, 2000·Bone·J RittwegerD Felsenberg
Jan 24, 2009·Nature Reviews. Cancer·Darci T ButcherValerie M Weaver
Mar 16, 2002·European Journal of Clinical Investigation·T UelandJ Bollerslev
Oct 9, 2013·Annual Review of Cell and Developmental Biology·Tadanori MammotoDonald E Ingber
Feb 11, 2009·Medicine and Science in Sports and Exercise·Désirée C WilksJörn Rittweger
Feb 23, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A L BoskeyR D Blank
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E N EbbesenL Mosekilde
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y DuanC H Turner
Apr 1, 2003·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·X Banse, J P Devogelaer
Dec 12, 2001·Clinical Oral Implants Research·T CaoK I Michi
Apr 5, 2013·Nutrition Reviews·Benjamin T Wall, Luc J C van Loon
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Jul 31, 2007·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Shilpa N BhupathirajuKenneth J Koehler
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Dec 9, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Alison A Murray, Marta C Erlandson

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