Nondisjunction and transmission ratio distortion ofChromosome 2 in a (2.8) Robertsonian translocation mouse strain.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Reiner SchulzR J Oakey

Abstract

Aneuploidy results from nondisjunction of chromosomes in meiosis and is the leading cause of developmental disabilities and mental retardation in humans. Therefore, understanding aspects of chromosome segregation in a genetic model is of value. Mice heterozygous for a (2.8) Robertsonian translocation were intercrossed with chromosomally normal mice and Chromosome 2 was genotyped for number and parental origin in 836 individuals at 8.5 dpc. The frequency of nondisjunction of this Robertsonian chromosome is 1.58%. Trisomy of Chromosome 2 with two maternally derived chromosomes is the most developmentally successful aneuploid karyotype at 8.5 dpc. Trisomy of Chromosome 2 with two paternally derived chromosomes is developmentally delayed and less frequent than the converse. Individuals with maternal or paternal uniparental disomy of Chromosome 2 were not detected at 8.5 dpc. Nondisjunction events were distributed randomly across litters, i.e., no evidence for clustering was found. Transmission ratio distortion is frequently observed in Robertsonian chromosomes and a bias against the transmission of the (2.8) Chromosome was detected. Interestingly, this was observed for female and male transmitting parents.

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Citations

Dec 18, 2012·Human Genetics·Lam Opal HuangClaire Infante-Rivard
Apr 20, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shawn FayerAnna K Naumova
May 10, 2008·Cytogenetic and Genome Research·M VozdovaJ Rubes
Apr 22, 2008·Journal of Cellular Biochemistry·Amanda Gonçalves Dos Santos SilvaSabine Mai
May 9, 2012·Journal of Molecular Modeling·Mohammed H Bohari, G Narahari Sastry
Sep 10, 2020·Genes·Marta Vázquez-GómezJoaquim Casellas

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

GLR

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