Nondysgerminomatous ovarian tumors: clinical characteristics, treatment, and outcome. A case-controlled study

International Journal of Surgery
Fatemeh GhaemmaghamiAzadeh Fallahi

Abstract

The aim of this study is to assess the response of patients with nondysgerminomatous ovarian germ-cell tumors (NDOGCT) to platinum-based chemotherapy and to determine association of prognostic factors to relapse of disease. We retrospectively reviewed 21 patients who had surgical resection of nondysgerminomatous ovarian germ-cell tumors (NDOGCT) and received adjuvant chemotherapy in Vali-e-Asr Hospital, Tehran, Iran during 1997-2004. The median age at presentation was 18 years and the median follow-up was 20 months. Histological type of tumors included the following: immature teratoma (n=7), mixed germ-cell tumor (n=7), yolk sac tumors (n=4), and embryonal carcinoma (n=3). Distribution by stage at the time of surgery was as follows; stage I (n=10), stage III (n=6), and stage IV (n=5). Sixteen patients underwent unilateral salpingo-oophorectomy and 5 patients underwent cystectomy. After the initial surgery, 13 patients immediately received chemotherapy and the other 8 patients received chemotherapy at a median time of 5.5 months (range, 1-40 months). Postoperative chemotherapy included the following: bleomycin, etoposide, and cisplatin (n=17); vincristine, actinomycin-D, and cyclophosphamide (n=2); methotrexate, etoposide, and c...Continue Reading

References

Jan 6, 1993·Journal of the National Cancer Institute·C R NicholsL H Einhorn
Jan 15, 2000·Obstetrics and Gynecology·K TewariM F Kohler
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Apr 22, 2004·Gynecologic Oncology·Mario E BeinerGilad Ben-Baruch

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Citations

Jul 1, 2016·Current Treatment Options in Oncology·Jin Li, Xiaohua Wu
Feb 1, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dimitrios NasioudisKevin Holcomb

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