Mar 24, 2016

Nonencapsulated Streptococcus pneumoniae: Emergence and Pathogenesis

MBio
L E KellerLarry S McDaniel

Abstract

While significant protection from pneumococcal disease has been achieved by the use of polysaccharide and polysaccharide-protein conjugate vaccines, capsule-independent protection has been limited by serotype replacement along with disease caused by nonencapsulatedStreptococcus pneumoniae(NESp). NESp strains compose approximately 3% to 19% of asymptomatic carriage isolates and harbor multiple antibiotic resistance genes. Surface proteins unique to NESp enhance colonization and virulence despite the lack of a capsule even though the capsule has been thought to be required for pneumococcal pathogenesis. Genes for pneumococcal surface proteins replace the capsular polysaccharide (cps) locus in some NESp isolates, and these proteins aid in pneumococcal colonization and otitis media (OM). NESp strains have been isolated from patients with invasive and noninvasive pneumococcal disease, but noninvasive diseases, specifically, conjunctivitis (85%) and OM (8%), are of higher prevalence. Conjunctival strains are commonly of the so-called classical NESp lineages defined by multilocus sequence types (STs) ST344 and ST448, while sporadic NESp lineages such as ST1106 are more commonly isolated from patients with other diseases. Interestingly...Continue Reading

  • References132
  • Citations31

References

Mentioned in this Paper

Tetracycline Antibiotics
Nasopharyngeal Diseases
Immune Response
Pathogenic Aspects
Tetracyclines
Monobactams
Disorder of Middle Ear
Malignant Neoplasm of Middle Ear
Choline
Entire Middle Ear

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