PMID: 9285065Aug 1, 1997

Nonenzymatic reduction of brucine N-oxide by the heme group of cytochrome P450

Biochemistry and Molecular Biology International
K TakekawaK Tatsumi

Abstract

Evidence showing that cytochrome P450-mediated reduction of brucine N-oxide to brucine by rat liver microsomes proceeds nonenzymatically in the presence of both a reduced pyridine nucleotide and FAD is presented. The microsomal N-oxide reduction appears to proceed in two steps: The first step is reduction of FAD by NADPH or NADH either enzymatically or nonenzymatically. The second step is nonenzymatic reduction of the tertiary amine N-oxide by the reduced flavin and is nonenzymatically catalyzed by the heme group of cytochrome P450.

Citations

Apr 10, 1999·The Journal of Pharmacy and Pharmacology·S KitamuraS Ohta
Apr 29, 2020·Alcoholism, Clinical and Experimental Research·Shoupeng WeiJian-Hui Liang
Jul 13, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ming ZhengYiqun Deng
Jan 21, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Peiqiang MuYiqun Deng

Related Concepts

Brucine N-oxide
Cyclic N-Oxides
Cytochrome P-450 Oxygenase
Heme
Microsomes, Liver
Protein Conformation
Strychnine Nitrate
Rats, Holtzman

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