PMID: 9285065Aug 1, 1997

Nonenzymatic reduction of brucine N-oxide by the heme group of cytochrome P450

Biochemistry and Molecular Biology International
K TakekawaK Tatsumi


Evidence showing that cytochrome P450-mediated reduction of brucine N-oxide to brucine by rat liver microsomes proceeds nonenzymatically in the presence of both a reduced pyridine nucleotide and FAD is presented. The microsomal N-oxide reduction appears to proceed in two steps: The first step is reduction of FAD by NADPH or NADH either enzymatically or nonenzymatically. The second step is nonenzymatic reduction of the tertiary amine N-oxide by the reduced flavin and is nonenzymatically catalyzed by the heme group of cytochrome P450.


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Related Concepts

Brucine N-oxide
Cyclic N-Oxides
Cytochrome P-450 Oxygenase
Microsomes, Liver
Protein Conformation
Strychnine Nitrate
Rats, Holtzman

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