Nonenzymatic, self-elimination degradation mechanism of glutathione

Chemistry & Biodiversity
Manjeet DeshmukhPatrick J Sinko

Abstract

In the present in vitro studies, evidence is provided showing that glutathione (GSH) can undergo spontaneous, nonenzymatic auto-degradation. The initial cleavage of the Glu-Cys bond involves nucleophilic attack of the N-terminal amino group of GSH at the gamma-carbonyl side chain, followed by an unusual cleavage of the Cys-Gly amide bond that is complete within 3-5 weeks in the physiological pH range. These observations may be useful for the development of novel biodegradable polymers and releasable prodrugs for sustained and targeted drug delivery applications.

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Related Concepts

Liquid Chromatography
Reduced Glutathione
In Vivo NMR Spectroscopy
Mass Spectrometry
Cysteine
Glutathione
Prodrugs
Cysteinylglycine
Drug Delivery Systems
Proteolysis

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