Nonenzymatically glycated albumin (Amadori adducts) enhances nitric oxide synthase activity and gene expression in endothelial cells.

Kidney International
Alessandro AmoreRosanna Coppo

Abstract

Hyperglycemia is considered to induce diabetic nephropathy through nonenzymatic glycation of proteins. Since hyperfiltration is likely to be the mechanism initiating the glomerular lesions, we investigated the effects of Amadori glucose adducts in serum albumin on the production of vasoactive mediators, including nitric oxide (NO) and eicosanoids, by endothelial cells (EC). Amadori adducts of glycated albumin induced a dose-response increase in NO synthase activity of murine endothelioma cells, up to 16.4 +/- 2.1-fold increase of basal values (P < 0.0001) at concentrations of 35 mg/ml mimicking physiological serum albumin concentration, and 4.6 +/- 0.8-fold increase at 17 mg/ml (P < 0.001). The effect was still detectable with glycated albumin 1.7 mg/ml, which approaches its estimated concentration in diabetic serum (1.6 +/- 0.3-fold increase, P < 0.05) The phenomenon was reproducible in human umbilical vein endothelial cells, though to a lesser extent, and further studies on murine EC were employed. The mRNA encoding for inducible NO synthase was overexpressed in EC incubated with Amadori adducts of glycated albumin in comparison to native albumin. Glycated albumin induced increased mRNA expression and synthesis of TNF-alpha. ...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C E GuthrowJ W Baynes
Dec 18, 1992·Science·J S StamlerJ Loscalzo
Oct 1, 1992·Kidney International·M SabbatiniV E Andreucci
Oct 1, 1992·International Journal of Sports Medicine·S Lahiri, P G Data
Sep 19, 1991·The New England Journal of Medicine·Z MakitaH Vlassara
Mar 1, 1990·The Journal of Clinical Investigation·B TesfamariamR A Cohen
Sep 1, 1989·Journal of Immunological Methods·M P Cohen, E Hud
Feb 8, 1989·Journal of Immunological Methods·M P Cohen, E Hud
May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
Feb 13, 1986·The New England Journal of Medicine·V M MonnierR R Kohn
Dec 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Oct 1, 1984·Annals of Internal Medicine·M BrownleeA Cerami
Oct 1, 1984·The Journal of Clinical Investigation·S M MauerF C Goetz
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V M MonnierA Cerami
Mar 1, 1981·Kidney International·T H HostetterB M Brenner
Nov 1, 1980·The Journal of Clinical Investigation·S L Schnider, R R Kohn
Jan 1, 1995·Annual Review of Physiology·S S Gross, M S Wolin
Jul 1, 1995·Kidney International·L Raij, C Baylis
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T YamamotoW A Border
Feb 9, 1995·Molecular and Cellular Biochemistry·M P CohenF N Ziyadeh
Feb 1, 1994·Kidney International·M P Cohen, F N Ziyadeh
Nov 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F R DeRubertis, P A Craven
Jun 1, 1993·Kidney International·N Bank, H S Aynedjian

❮ Previous
Next ❯

Citations

Jun 9, 2001·Biochemical and Biophysical Research Communications·V Y WuM P Cohen
Oct 26, 2005·Zeitschrift für Gerontologie und Geriatrie·J WebsterG Münch
Mar 23, 2002·European Journal of Pharmacology·Chien-Huang LinHorng-Mo Lee
Aug 12, 1999·European Journal of Pharmacology·D A GreeneE L Feldman
Sep 21, 2002·Molecular and Cellular Endocrinology·Chih-Hsiung WuHorng-Mo Lee
Feb 12, 2004·Kidney International. Supplement·Anand VardhanRaymond T Krediet
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandro AmoreRosanna Coppo
Jun 28, 2011·American Journal of Nephrology·Carolina Sánchez-RodríguezJulián Nevado
Sep 2, 2004·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Xiao-Jing ZhouLan Huang
May 25, 2002·Kidney International·Margo P CohenSheldon Chen
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bernhard Schaller, Rudolf Graf
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A HeidlandR Schinzel
Jul 23, 2005·Annals of the New York Academy of Sciences·Ryuichi Wada, Soroku Yagihashi
Jul 6, 2005·British Journal of Pharmacology·Julián NevadoLeocadio Rodríguez-Mañas
Jul 15, 2004·Seminars in Nephrology·Sharma S Prabhakar
May 16, 2006·The Journal of Laboratory and Clinical Medicine·Margo P CohenSheldon Chen
Mar 4, 1999·The Korean Journal of Internal Medicine·K C ChoiY J Kang
Jan 27, 2015·Neuroscience Letters·Christopher R Cashman, Ahmet Höke
Aug 6, 2016·International Journal of Biological Macromolecules·K M NeelofarKhursheed Alam
Aug 3, 2002·European Journal of Clinical Investigation·C G SchalkwijkUNKNOWN EUCLID Study Group
Mar 19, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Varun Parkash SinghAmteshwar Singh Jaggi
Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·T A KentR H Fabian
Jul 15, 2005·American Journal of Physiology. Renal Physiology·I Londono, M Bendayan
Nov 4, 2011·Molecular and Cellular Biochemistry·Savita BansalAshok K Tripathi
May 1, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G La GrecaG Gambaro
Sep 1, 2000·American Journal of Physiology. Renal Physiology·R KomersS Anderson
Jun 16, 2001·American Journal of Physiology. Renal Physiology·S S Prabhakar
Jan 3, 2001·American Journal of Physiology. Renal Physiology·I Londoño, M Bendayan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Alessandro AmoreRosanna Coppo
Biochemical and Biophysical Research Communications
M P CohenC W Shearman
© 2022 Meta ULC. All rights reserved