PMID: 8595706Dec 1, 1995Paper

Nonenzymic glycation of apolipoprotein B in patients with insulin- and noninsulin-dependent diabetes mellitus

Clinical Biochemistry
M PanteghiniA Girelli

Abstract

To evaluate the level of nonenzymatic glycation of apolipoprotein B in patients with insulin and noninsulin dependent diabetes mellitus. Using a method based on a combination of affinity chromatography and immunonephelometry, we measured the concentration of glycated apolipoprotein B (apo B) in serum of 140 diabetic patients, 43 insulin-dependent (IDDM), and 97 noninsulin-dependent (NIDDM), and 45 nondiabetic control subjects. Although total apo B concentration in serum was significantly increased only in NIDDM patients, both groups of diabetics showed higher percentages of glycated apo B (IDDM, 4.84 +/- 0.8%; NIDDM, 5.61 +/- 1.1%) than did control subjects (4.28 +/- 1.0%), the greatest percentage (5.80%) being found in patients with diabetic nephropathy. No significant correlations were found between glycated apo B and the traditional parameters of glycemic control, such as glycated hemoglobin and fructosamines, and direct influence by sudden plasma glucose fluctuations on apo B glycation was not shown either, perhaps for a low inherent glycability of this apolipoprotein. It is unclear if these low proportions of glycated apo B in vivo may significantly affect lipoprotein metabolism assuming a pathophysiological role in athero...Continue Reading

References

Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E L Bierman
Dec 29, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·W KortlandtJ H Thijssen
Jul 18, 1986·Biochimica Et Biophysica Acta·J E TriauE J Schaefer
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Apr 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·A Gugliucci Creriche, A J Stahl

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Citations

Nov 29, 2015·Diabetes & Metabolic Syndrome·Kapil DevS V Madhu
Sep 30, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Nahla N YounisPaul N Durrington

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