Nonequivalent response to bromodomain-targeting BET inhibitors in oligodendrocyte cell fate decision

Chemistry & Biology
Cheng-Ming Chiang


The tandem bromodomains (BD1 and BD2) of the BET family proteins BRD2, BRD3, BRD4, and BRDT are structurally conserved but not functionally equivalent. In this issue of Chemistry & Biology, Gacias and colleagues report that a BD1-specific chemical inhibitor, Olinone, enhances oligodendrocyte differentiation, contrasting the reverse process triggered by broad BD1/BD2-targeting inhibitors, highlighting distinct roles of BD1 and BD2 in cell fate decision.


Jun 11, 2016·Biochemical and Biophysical Research Communications·Olesya A KharenkoHenrik C Hansen
Oct 23, 2016·Drug Discovery Today. Technologies·Cheng-Ming Chiang
Oct 24, 2015·Chemical Reviews·Guangtao ZhangMing-Ming Zhou
Aug 17, 2019·American Journal of Respiratory and Critical Care Medicine·Soni Savai Pullamsetti, Vinicio A de Jesus Perez
Sep 15, 2020·Medicinal Research Reviews·Ewelina KulikowskiNorman C W Wong
Jul 18, 2017·Archiv der Pharmazie·Mostafa Radwan, Rabah Serya
May 25, 2020·Molecular Cell·Shwu-Yuan WuCheng-Ming Chiang
Dec 20, 2017·Molecular and Cellular Neurosciences·Elijah KoremanQ Richard Lu

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