Nonequivalent response to bromodomain-targeting BET inhibitors in oligodendrocyte cell fate decision

Chemistry & Biology
Cheng-Ming Chiang

Abstract

The tandem bromodomains (BD1 and BD2) of the BET family proteins BRD2, BRD3, BRD4, and BRDT are structurally conserved but not functionally equivalent. In this issue of Chemistry & Biology, Gacias and colleagues report that a BD1-specific chemical inhibitor, Olinone, enhances oligodendrocyte differentiation, contrasting the reverse process triggered by broad BD1/BD2-targeting inhibitors, highlighting distinct roles of BD1 and BD2 in cell fate decision.

Citations

Jun 11, 2016·Biochemical and Biophysical Research Communications·Olesya A KharenkoHenrik C Hansen
Oct 23, 2016·Drug Discovery Today. Technologies·Cheng-Ming Chiang
Oct 24, 2015·Chemical Reviews·Guangtao ZhangMing-Ming Zhou
Aug 17, 2019·American Journal of Respiratory and Critical Care Medicine·Soni Savai Pullamsetti, Vinicio A de Jesus Perez
Sep 15, 2020·Medicinal Research Reviews·Ewelina KulikowskiNorman C W Wong
Jul 18, 2017·Archiv der Pharmazie·Mostafa Radwan, Rabah Serya
May 25, 2020·Molecular Cell·Shwu-Yuan WuCheng-Ming Chiang
Dec 20, 2017·Molecular and Cellular Neurosciences·Elijah KoremanQ Richard Lu

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