Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions

Journal of Pediatric Gastroenterology and Nutrition
Sara Naramore, Sandeep K Gupta

Abstract

Eosinophilic gastrointestinal disorders are a set of conditions with a wide range of clinical manifestations and treatment modalities. The disorders are suspected to result from an abnormal inflammatory response to allergen (s), and individuals may develop a relapsing or chronic disease, if the allergen is not eliminated. Mechanisms of disease pathogenesis, including the humoral immune response, need to be fully elucidated. A variety of therapies are used, although there is a lack of well-defined randomized, prospective studies. Other therapeutic options are needed as the current treatments have potential concerns; elimination diets may impair a child's quality of life, and corticosteroids have adverse risks with long-term use. We review what is known about nonesophageal eosinophilic gastrointestinal disorders, and discuss research investigations which need to be conducted to facilitate diagnosis and enhance treatment methods.

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Citations

May 31, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alfredo J Lucendo, Piedad López-Sánchez
Feb 2, 2021·Gastroenterology Clinics of North America·Emily Hon, Sandeep K Gupta
May 12, 2021·BMJ Case Reports·Harry Jin, Kellee Slater

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