Nonesterified fatty acids induce transmembrane monovalent cation flux: host-guest interactions as determinants of fatty acid-induced ion transport

Biochemistry
Y ZengR W Gross

Abstract

Nonesterified fatty acids are key intermediates in cellular metabolism whose intracellular concentration is regulated by multiple anabolic, catabolic, and oxidative enzymatic cascades. Herein, we demonstrate that fatty acids induce transmembrane monovalent cation flux with an apparent rate constant kapp = 10(-)4 - 10(-)3 s-1. Fatty acid-induced cation efflux exploits the ionic association of the cation with the carboxylate anion of the fatty acid and the subsequent transmembrane flip-flop of the fatty acid-cation complex. Rates of fatty acid-induced transmembrane cation flux were dependent upon complex host-guest interactions between the fatty acid-cation complex and the phospholipid constituents which comprise the membrane bilayer including (1) the degree of unsaturation of the fatty acid guest and the regiospecificity and stereospecificity of its olefinic linkages; (2) the phospholipid subclass and individual molecular species which constitute the host membrane phospholipids; (3) impedance matching of host and guest hydrophobic characteristics; and (4) the cholesterol content of the membrane bilayer. Arrhenius analysis demonstrated that fatty acid-induced K+ efflux was facilitated largely by changes in the entropy of activati...Continue Reading

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Citations

Jun 14, 2002·Archives of Biochemistry and Biophysics·Peter SchönfeldLech Wojtczak
Feb 29, 2000·Molecular and Biochemical Parasitology·R CatistiA E Vercesi
Jun 4, 2010·Cold Spring Harbor Perspectives in Biology·Irene A Chen, Peter Walde
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Irene A Chen, Jack W Szostak
Mar 1, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ayumi HiranoMasao Sugawara
Aug 16, 2005·Prostaglandins & Other Lipid Mediators·Richard W GrossXianlin Han
Feb 1, 2007·Meat Science·E MurielJ Ruiz
Jan 3, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Georg ReiserStefan Kahlert
Apr 20, 2012·Psychiatry Research·Rima Kaddurah-DaoukHenry A Nasrallah
May 27, 2003·Biochimica Et Biophysica Acta·Peter SchönfeldLech Wojtczak
Jul 11, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Teresa M FonovichJorge Herkovits
Apr 25, 2018·Rapid Communications in Mass Spectrometry : RCM·B Sudarshana ReddyS Prabhakar
Jan 25, 2007·American Journal of Physiology. Renal Physiology·Thorsten FeldkampJoel M Weinberg

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