Abstract
To investigate associations of estimated cardiorespiratory fitness (eCRF) and all-cause and cardiovascular disease (CVD) mortality in a representative US population. A total of 12,834 participants, aged 20 to 86 years at baseline, were included in the Third National Health and Nutrition Examination Survey. They were followed up from October 18, 1988, through December 31, 2011, for all-cause and CVD death. Cardiorespiratory fitness was estimated from a nonexercise algorithm and further grouped into tertiles. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% CIs. A total of 3439 deaths (999 due to CVD) occurred during median follow-up of 19.2 years. After adjusting for race/ethnicity, education, age, hypertension, diabetes, hypercholesterolemia, baseline CVD, and cancer status, each metabolic equivalent increase of eCRF was associated with an 18% (range, 15%-21%) lower risk of all-cause mortality and a 19% (range, 15%-24%) lower risk of CVD mortality in men and a 24% (range, 20%-28%) lower risk of all-cause mortality and a 24% (18%-30%) lower risk of CVD mortality in women. Compared with the lower eCRF group, the HRs (95% CIs) of the middle and upper groups were 0.72 (0.61-0.85) and 0.56 (0.47-0.6...Continue Reading
References
Nov 24, 1988·The New England Journal of Medicine·L G EkelundD S Sheps
Jan 1, 1993·Medicine and Science in Sports and Exercise·B E AinsworthR S Paffenbarger
Feb 25, 1993·The New England Journal of Medicine·L SandvikK Rodahl
Sep 1, 1996·Annals of Epidemiology·J B KampertH W Kohl
Mar 1, 1997·Medicine and Science in Sports and Exercise·J D GeorgeL N Burkett
Apr 3, 1999·Medicine and Science in Sports and Exercise·C E MatthewsH Pastides
Mar 27, 2001·Archives of Internal Medicine·J A LaukkanenJ T Salonen
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
Sep 25, 2003·JAMA : the Journal of the American Medical Association·Samia MoraRoger S Blumenthal
Jul 27, 2005·Circulation·Jerome L FlegEdward G Lakatta
Sep 20, 2005·American Journal of Preventive Medicine·Radim JurcaRaija Laukkanen
Jun 3, 2006·Research Quarterly for Exercise and Sport·Danielle I BradshawFrank G Yanowitz
Jul 25, 2007·Journal of Internal Medicine·J A LaukkanenS Kurl
May 21, 2009·JAMA : the Journal of the American Medical Association·Satoru KodamaHirohito Sone
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Srinivasan BeddhuTom Greene
Oct 28, 2009·Archives of Internal Medicine·Andrew S JacksonSteven N Blair
Jun 30, 2010·Circulation·Gary J BaladyUNKNOWN Interdisciplinary Council on Quality of Care and Outcomes Research
Aug 11, 2010·Circulation·Peter KokkinosRoss Fletcher
Oct 15, 2010·Journal of Psychopharmacology·Duck-chul LeeSteven N Blair
Apr 20, 2011·Medicine and Science in Sports and Exercise·Bjarne Martens NesUlrik Wisløff
Jun 23, 2011·Medicine and Science in Sports and Exercise·Carol Ewing GarberUNKNOWN American College of Sports Medicine
Dec 7, 2011·Circulation·Duck-chul LeeSteven N Blair
May 5, 2012·European Heart Journal·Emmanuel StamatakisMika Kivimaki
Oct 20, 2012·American Journal of Preventive Medicine·Andrew S JacksonSteven N Blair
Jul 23, 2013·Circulation. Heart Failure·Stephen W FarrellWilliam L Haskell
Apr 8, 2014·Journal of the American College of Cardiology·Enrique G ArteroSteven N Blair
Jul 9, 2014·Medicine and Science in Sports and Exercise·David Martinez-GomezFernando Rodríguez-Artalejo
Aug 3, 2014·Archives of Gerontology and Geriatrics·Geraldo A Maranhao NetoPaulo T V Farinatti
Jul 4, 2015·Circulation Research·Carl J LavieSteven N Blair
Dec 24, 2015·Medicine and Science in Sports and Exercise·Gary O'DonovanJason M R Gill
Jul 23, 2016·Mayo Clinic Proceedings·Jari A LaukkanenRainer Rauramaa
Sep 7, 2016·Mayo Clinic Proceedings·Ovuokerie AddohPaul D Loprinzi
Nov 2, 2016·Future Cardiology·Carl J LavieSteven N Blair
Nov 22, 2016·Mayo Clinic Proceedings·Javaid NaumanUlrik Wisløff
Nov 24, 2016·Mayo Clinic Proceedings·Peter F KokkinosRoss Fletcher
Nov 25, 2016·Circulation·Robert RossUNKNOWN Stroke Council
Citations
Apr 18, 2019·Journal of the American Heart Association·Rajesh ShigdelLinda Ernstsen
Jul 4, 2020·Heart·Verónica Cabanas-SánchezDavid Martínez-Gómez
Feb 25, 2021·European Journal of Preventive Cardiology·Baruch VainshelboimCharles E Matthews
Jul 6, 2021·Atherosclerosis·Shanhu QiuUwe Schumann
Sep 19, 2018·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Thomas C Gerber
Oct 30, 2021·JAMA Network Open·Joowon LeeVanessa Xanthakis
Jul 4, 2018·Deutsches Ärzteblatt International·Herbert Löllgen, Dieter Leyk