Nonfunctioning progesterone receptors in the developed oviducts from estrogen-withdrawn immature chicks and in aged nonlaying hens

Endocrinology
P A Boyd-LeinenT C Spelsberg

Abstract

The progesterone receptor (PR) in the oviducts of aged, nonlaying hens was compared to that in laying hens. The PRs in the mature oviducts of chicks that were diethylstilbestrol (DES) primed and of chicks with DES withdrawn were similarly analyzed for comparative purposes. The oviducts from the DES-withdrawn chicks and from aged nonlaying hens showed marked atrophy. The PR concentrations in the oviducts of DES-withdrawn chicks and of aged nonlaying hens were reduced to one half and one fourth those of controls, respectively. The oviduct atrophy and reduced PR concentrations in the nonlaying hen were not caused by decreased plasma estrogen since estrogen concentrations were similar in aged nonlaying hen and in the laying hens. The stabilities of the PR from laying and nonlaying hen oviducts were identical. However, analysis in vivo and in vitro revealed that the PR from the oviducts of DES-withdrawn chicks and of aged, nonlaying hens had lost the capacity for nuclear translocation and binding. This was accompanied in the DES-withdrawn chick by the inability of progesterone to alter RNA synthesis in the oviduct in vivo. This loss in nuclear binding capacity of PR in both animal models was accompanied by a loss of one of the molec...Continue Reading

Citations

Jul 1, 1979·Journal of Steroid Biochemistry·T C SpelsbergG Martin-Dani
Jan 1, 1987·Journal of Steroid Biochemistry·T C SpelsbergJ Hora
Oct 1, 1988·Journal of Steroid Biochemistry·T C SpelsbergR Singh
Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·W SchneiderG Shyamala
Dec 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·M K MohamedKathryn B Horwitz
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·J D GrahamC L Clarke
Aug 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·H SyväläP Tuohimaa
May 23, 1998·Breast Cancer Research and Treatment·Jennifer K RicherKathryn B Horwitz
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T Zarucki-SchulzB W O'Malley
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H ToyodaT C Spelsberg
Jun 1, 1996·Clinical Obstetrics and Gynecology·J H PinterO K Park-Sarge
Jul 13, 2001·Anatomia, histologia, embryologia·Genoveva González-Morán, Ignacio Camacho-Arroyo
Sep 26, 2008·Domestic Animal Endocrinology·María Genoveva González-MoránIgnacio Camacho-Arroyo
Dec 5, 2006·General and Comparative Endocrinology·Ignacio Camacho-ArroyoMaría Genoveva González-Morán
Sep 13, 2014·Journal of Cellular and Molecular Medicine·Francesca De AmicisSebastiano Andò
Jul 4, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ignacio Camacho-ArroyoGenoveva González-Morán
Aug 15, 1986·Archives of Biochemistry and Biophysics·B O FangerJ A Cidlowski
Aug 17, 2016·Biochemical and Biophysical Research Communications·María Genoveva González-Morán
Aug 1, 1997·Endocrine Reviews·J D Graham, C L Clarke
Nov 22, 2001·The Journal of Biological Chemistry·Jennifer K RicherKathryn B Horwitz

Related Concepts

Senility
Cell Nucleus
Estrogen Effect
Isoelectric Focusing
Animal Oviduct
Progesterone, (9 beta,10 alpha)-Isomer
Receptors, Progesterone

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Related Papers

Reproduction : the Official Journal of the Society for the Study of Fertility
Carmela GuidoSaveria Aquila
Archives of Biochemistry and Biophysics
Chih-Hao SuWei-Ping Lee
© 2021 Meta ULC. All rights reserved