Nongenomic effects of aldosterone on phosphocreatine levels in human calf muscle during recovery from exercise

The Journal of Clinical Endocrinology and Metabolism
J ZangeM Wehling

Abstract

Nongenomic in vitro effects of aldosterone on the sodium-proton antiport and intracellular second messengers have been described in human mononuclear leukocytes, vascular smooth muscle cells, and endothelial cells. To test the potential physiological relevance of these effects, an in vivo 31P magnetic resonance spectroscopy study on the human calf at rest and during exercise was performed in 10 healthy volunteers receiving either 1 mg aldosterone or placebo iv in a double blind, randomized, cross-over trial. Spectra were analyzed for phosphocreatine, ATP, phosphomonoesters, inorganic intracellular phosphate, and intracellular pH. Resting values remained unchanged by aldosterone. After isometric contraction of the calf (50% body weight for 3 min), phosphocreatine recovered to significantly higher levels after application of aldosterone compared with placebo. Other parameters were not significantly changed by aldosterone. Effects appeared immediately after isometric contraction and, thus, occurred within 8 min of aldosterone administration. They are, therefore, likely to represent the first contemporary evidence of nongenomic in vivo effects of aldosterone in man. These findings also point to an involvement of aldosteron in the a...Continue Reading

Citations

Nov 1, 2001·Journal of Endocrinological Investigation·M ChristM Wehling
Jan 22, 2003·Atherosclerosis·Paola RomagniVittorio Santiemma
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Ralf LöselMartin Wehling
Apr 12, 2000·Kidney International·E FalkensteinM Wehling
Apr 28, 2004·Biochemical and Biophysical Research Communications·Karin Rossol-HaserothRalf M Lösel
Feb 9, 2000·Frontiers in Neuroendocrinology·B M SchmidtM Wehling
Oct 18, 2007·Pflügers Archiv : European journal of physiology·Jochen ZangeNorbert Maassen
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·E FalkensteinM Wehling
Jul 5, 2003·Physiological Reviews·Ralf M LoselMartin Wehling

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