Nonhormonal treatments for heavy menstrual bleeding

Journal of Women's Health
Måns Edlund

Abstract

The purpose of this review is to identify and compare nonhormonal medications for the treatment of idiopathic heavy menstrual bleeding (HMB) or menorrhagia. Clinical trials were identified through a PubMed literature search. Titles and abstracts of identified studies were reviewed. Controlled clinical trials that evaluated nonhormonal medications in women with HMB in the absence of anatomic abnormalities other than small fibroids were selected for retrieval. Additional studies were identified from the reference lists of selected articles. Selected articles were comprehensively reviewed. All medications evaluated reduced menstrual blood loss (MBL); however, mean reductions in MBL were greatest with the hemostatic agents, tranexamic acid (TA) and ε-aminocaproic acid. Several TA studies also included evidence of improvement in health-related quality of life (HRQOL). Reductions in MBL were generally smaller and less consistent with nonsteroidal anti-inflammatory drug (NSAID) treatment. All medications reviewed were well tolerated. Nonhormonal medications used for HMB treatment differ in the extent of MBL reduction. TA was notable for consistent MBL reductions and improvement in HRQOL; other agents reviewed indicated less reduction ...Continue Reading

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Citations

Mar 29, 2014·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Marie MawetJean-Michel Foidart
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May 2, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Claudia Djambas KhayatRezan Abdul Kadir

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Methods Mentioned

BETA
hysterectomy
contraception
PBAC

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