Nonhuman primate induced pluripotent stem cells in regenerative medicine.

Stem Cells International
Yuehong WuPeter J Hornsby

Abstract

Among the various species from which induced pluripotent stem cells have been derived, nonhuman primates (NHPs) have a unique role as preclinical models. Their relatedness to humans and similar physiology, including central nervous system, make them ideal for translational studies. We review here the progress made in deriving and characterizing iPS cell lines from different NHP species. We focus on iPS cell lines from the marmoset, a small NHP in which several human disease states can be modeled. The marmoset can serve as a model for the implementation of patient-specific autologous cell therapy in regenerative medicine.

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Citations

Feb 13, 2016·Veterinary Pathology·H A Simmons
Apr 20, 2013·Experimental Biology and Medicine·Steven L FarnsworthPeter J Hornsby
Dec 24, 2013·The Journal of Biological Chemistry·John Harding, Oleg Mirochnitchenko
Sep 20, 2018·International Journal of Molecular Sciences·Guang YangMarcel M Daadi
Aug 6, 2020·International Journal of Molecular Sciences·Daniela Gois BeghiniAndrea Henriques-Pons

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Methods Mentioned

BETA
transgenic
transgenics
biopsies
genetic modification

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