Nonhuman primate models in type 1 diabetes research

ILAR Journal
Juan L ContrerasDevin E Eckhoff

Abstract

The recent success of "steroid-free" immunosuppressive protocols and improvements in islet preparation techniques have proven that pancreatic islet transplantation (PIT) is a valid therapeutic approach for patients with type 1 diabetes. However, there are major obstacles to overcome before PIT can become a routine therapeutic procedure, such as the need for chronic immunosuppression, the loss of functional islet mass after transplantation requiring multiple islet infusion to achieve euglycemia without exogenous administration of insulin, and the shortage of human tissue for transplantation. With reference to the first obstacle, stable islet allograft function without immunosuppressive therapy has been achieved after tolerance was induced in diabetic primates. With reference to the second obstacle, different strategies, including gene transfer of antiapoptotic genes, have been used to protect isolated islets before and after transplantation. With reference to the third obstacle, pigs are an attractive islet source because they breed rapidly, there is a long history of porcine insulin use in humans, and there is the potential for genetic engineering. To accomplish islet transplantation, experimental opportunities must be balanced...Continue Reading

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Citations

Jul 2, 2004·ILAR Journal·Stephen W Barthold
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·S Thomas Carmichael
Mar 20, 2010·Advanced Drug Delivery Reviews·Keiji Numata, David L Kaplan
Sep 8, 2011·Journal of Medical Primatology·Yi ZhangBo-Le Tian
Jul 10, 2012·Journal of Diabetes Science and Technology·H James HarwoodJanice D Wagner

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