Nonhuman Primate Ocular Biometry

Investigative Ophthalmology & Visual Science
Robert C AugusteynJean-Marie Parel

Abstract

To examine ocular growth in nonhuman primates (NHPs) from measurements on ex vivo eyes. We obtained NHP eyes from animals that had been killed as part of other studies or because of health-related issues. Digital calipers were used to measure the horizontal, vertical, and anteroposterior globe diameters as well as corneal horizontal and vertical diameters of excised globes from 98 hamadryas baboons, 551 cynomolgus monkeys, and 112 rhesus monkeys, at ages ranging from 23 to 360 months. Isolated lens sagittal thickness and equatorial diameter were measured by shadowphotogrammetry. Wet and fixed dry weights were obtained for lenses. Nonhuman primate globe growth continues throughout life, slowing toward an asymptotic maximum. The final globe size scales with negative allometry to adult body size. Corneal growth ceases at around 20 months. Lens diameter increases but thickness decreases with increasing age. Nonhuman primate lens wet and dry weight accumulation is monophasic, continuing throughout life toward asymptotic maxima. The dry/wet weight ratio reaches a maximum of 0.33. Nonhuman primate ocular globe and lens growth differ in several respects from those in humans. Although age-related losses of lens power and accommodative a...Continue Reading

Citations

May 26, 2018·Investigative Ophthalmology & Visual Science·Bianca Maceo HeilmanJean-Marie Parel
Aug 21, 2020·Translational Vision Science & Technology·Yu-Chi LiuJodhbir S Mehta
Nov 1, 2018·Clinical & Experimental Ophthalmology·Aparna MuraliChristopher J Layton
Jan 5, 2021·Investigative Ophthalmology & Visual Science·Kwame Antwi-BoasiakoNimesh Patel
Mar 25, 2021·Health Physics·Kenneth R FosterSteven Chalfin
Jul 5, 2021·Ophthalmology and Therapy·Lixiang WangHui Zhang

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