Nonhypervascular Hypointense Nodules at Gadoxetic Acid-enhanced MR Imaging in Chronic Liver Disease: Diffusion-weighted Imaging for Characterization

Radiology
Jiyoung HwangWon Jae Lee

Abstract

To compare the diagnostic performance of magnetic resonance (MR) imaging features, including those on diffusion-weighted (DW) and T2-weighted images, in differentiating between hypovascular hepatocellular carcinoma (HCC) and dysplastic nodules seen as hypointense nodules at hepatobiliary phase gadoxetic acid-enhanced MR imaging. The institutional review board approved this retrospective study and waived the need to obtain informed patient consent. There were 53 patients (39 men and 14 women; age range, 32-75 years) with histologically proven hypovascular HCCs (n = 25) and/or dysplastic nodules (n = 31) who underwent gadoxetic acid-enhanced MR imaging at 3.0-T between March 2011 and January 2014. Images of 25 HCCs and 31 dysplastic nodules were analyzed for nodule size; signal intensity on T1- and T2-weighted, portal venous phase, and DW (b value = 800 sec/mm(2)) images; and intralesional fat. Correlations between the hyperintensity grade of lesions and the liver-to-lesion signal intensity ratio at T2-weighted and DW imaging were determined by means of analysis with generalized estimating equations. Hyperintensity at T2-weighted and DW imaging and hypointensity in the portal venous phase were significant features for differentia...Continue Reading

References

Sep 23, 2000·AJR. American Journal of Roentgenology·T KimM A Nalesnik
Jan 24, 2004·Radiology·Hero K HussainIsaac R Francis
May 27, 2005·Seminars in Liver Disease·Masamichi Kojiro, Tania Roskams
Jun 15, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luigi BolondiFabio Piscaglia
Jul 18, 2009·Academic Radiology·Kumaresan SandrasegaranAlex M Aisen
May 19, 2011·Journal of Computer Assisted Tomography·Bilal BattalNail Bulakbasi
Oct 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas SerstéFrançoise Degos
Mar 1, 2013·Expert Review of Gastroenterology & Hepatology·An TangClaude B Sirlin
Mar 28, 2013·Statistics in Medicine·Chaeryon KangJianwen Cai
Nov 1, 2013·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Dai JoishiSachio Kuribayashi

❮ Previous
Next ❯

Citations

Feb 9, 2016·Diagnostics·Christina SchramlKonstantin Nikolaou
Oct 19, 2016·Journal of Hepatology·Maxime RonotAndrea Frilling
Oct 6, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Milena CernyAn Tang
Jan 13, 2016·World Journal of Gastroenterology : WJG·Francesco AgnelloGiuseppe Brancatelli
Jan 5, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Wentao WangSheng-Xiang Rao
Jul 24, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jae Hyun KimJeong Min Lee
Aug 7, 2018·World Journal of Hepatology·Zeno Sparchez, Tudor Mocan
Aug 12, 2015·World Journal of Hepatology·António P MatosRichard C Semelka
May 4, 2017·Infectious Agents and Cancer·Vincenza GranataAntonella Petrillo
Aug 7, 2018·World Journal of Hepatology·Riccardo InchingoloDavide Ippolito
Mar 21, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Dong Ik ChaSoo Hyun Ahn
May 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·UNKNOWN Korean Society of Abdominal Radiology
Oct 15, 2020·AJR. American Journal of Roentgenology·Robert M MarksVictoria Chernyak
Jul 21, 2021·Infectious Agents and Cancer·Vincenza GranataAntonella Petrillo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.