Noninfectious complications of common variable immune deficiency

Allergy and Asthma Proceedings
Lisa J Kobrynski

Abstract

Background: Common variable immune deficiency (CVID) is a primary immune deficiency due to defective B-cell maturation. Objective: To improve recognition of noninfectious complications of CVID and increase awareness of appropriate interventions for noninfectious complications of CVID. Methods: To review the diagnosis and treatment of CVID with infectious and noninfectious complications. Results: A case of a woman with CVID with autoimmunity and gastrointestinal complications is presented with a discussion of the recognition and treatment of infectious and noninfectious complications. Conclusion: Patients with CVID must be monitored for noninfectious complications, e.g., inflammatory disease of the lung and gastrointestinal tract, because these are associated with decreased survival.

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