Noninfectious transfusion-associated adverse events and their mitigation strategies.

Blood
Ruchika GoelBeth H Shaz

Abstract

Blood transfusions are life-saving therapies; however, they can result in adverse events that can be infectious or, more commonly, noninfectious. The most common noninfectious reactions include febrile nonhemolytic transfusion reactions, allergic transfusion reactions, transfusion-associated circulatory overload, transfusion-related acute lung injury, and acute and delayed hemolytic transfusion reactions. These reactions can be asymptomatic, mild, or potentially fatal. There are several new methodologies to diagnose, treat, and prevent these reactions. Hemovigilance systems for monitoring transfusion events have been developed and demonstrated decreases in some adverse events, such as hemolytic transfusion reactions. Now vein-to-vein databases are being created to study the interactions of the donor, product, and patient factors in the role of adverse outcomes. This article reviews the definition, pathophysiology, management, and mitigation strategies, including the role of the donor, product, and patient, of the most common noninfectious transfusion-associated adverse events. Prevention strategies, such as leukoreduction, plasma reduction, additive solutions, and patient blood management programs, are actively being used to en...Continue Reading

References

Sep 1, 1989·European Journal of Haematology·H FredlundD Filbey
Oct 20, 2001·European Journal of Health Law·Yvonne Göricke Nordlund, Lars Edgren
Oct 27, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jean-Claude Faber
May 26, 2007·Transfusion·Aaron A R TobianPaul M Ness
Nov 8, 2007·Current Allergy and Asthma Reports·Brett L Buchmiller, David A Khan
Jul 14, 2009·International Journal of Pediatric Otorhinolaryngology·Jonathan A PerkinsDimitri A Christakis
Feb 18, 2010·Transfusion·Gustaf EdgrenOlof Nyrén
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalNelcy Rodriguez-Malagon
Dec 24, 2010·Vox Sanguinis·R R P de VriesUNKNOWN Board of the International Haemovigilance Network
Jan 12, 2012·Transfusion·Matthew KarafinAaron A R Tobian
Aug 30, 2012·British Journal of Haematology·Hazel TinegateUNKNOWN BCSH Blood Transfusion Task Force
Sep 25, 2012·Transfusion·William J SavagePaul M Ness
Nov 6, 2013·Transfusion·Steven KleinmanUNKNOWN National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III)
Jan 18, 2014·American Journal of Clinical Pathology·Sarah K HarmMeghan Delaney
Apr 17, 2014·Transfusion·Claudia S CohnW Andrew Heaton
May 6, 2014·The Journal of Allergy and Clinical Immunology·William J SavagePaul M Ness
Oct 14, 2014·Transfusion·Miriam A MarkowitzPaul M Ness
Nov 11, 2014·Annals of Internal Medicine·Richard M KaufmanAaron A R Tobian
Jan 8, 2015·Transfusion·Koo-Whang ChungMatthew J Kuehnert
May 15, 2015·British Journal of Haematology·Kate GardnerSwee L Thein
Nov 4, 2015·The World Allergy Organization Journal·F Estelle R SimonsAziz Sheikh
Apr 17, 2016·Lancet·Meghan DelaneyUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Jul 28, 2016·Transfusion·Jeanne E HendricksonUNKNOWN National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study (REDS-III)
Oct 13, 2016·JAMA : the Journal of the American Medical Association·Jeffrey L CarsonAaron A R Tobian

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Citations

Dec 25, 2019·Transfusion·Beth H ShazChristopher R France
Jun 22, 2019·Blood·Beth H Shaz
Oct 3, 2019·The New England Journal of Medicine·Sandhya R PanchHarvey G Klein
Sep 7, 2020·Journal of Reconstructive Microsurgery·Efstathios KaramanosHoward T Wang
Oct 3, 2019·The New England Journal of Medicine·Tomohiko SatoTetsunori Tasaki
Nov 21, 2020·Acta Anaesthesiologica Scandinavica·Lars Broksø HolstLene Russell
Jan 27, 2021·Clinics in Laboratory Medicine·Nataliya Sostin, Jeanne E Hendrickson
Feb 16, 2021·Transfusion·Claudia S CohnAaron A R Tobian
Mar 23, 2021·Seminars in Oncology Nursing·Carrie A GrahamJeannine Sanford
Dec 9, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Ryu Yanagisawa
Apr 7, 2021·American Journal of Clinical Pathology·Tayler A van den AkkerMark T Friedman
May 6, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ilknur Kulhas CelikNamık Yasar Ozbek
Aug 17, 2021·Platelets·Peter Smethurst, Rebecca Cardigan
Aug 29, 2021·Transfusion·Ashutosh LalElliott Vichinsky

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