Noninferior response in BRAF(V600E) mutant nonmetastatic papillary thyroid carcinoma to radioiodine therapy

European Journal of Nuclear Medicine and Molecular Imaging
Jiao LiYan-song Lin

Abstract

As the most frequent and specific genetic alteration in papillary thyroid carcinoma (PTC), BRAF(V600E) has an intimate relationship with more invasive tumour and higher postoperative recurrence risk in PTC patients. We investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in PTC patients with the BRAF(V600E) mutation without distant metastases. This retrospective study included PTC 228 patients without distant metastases who underwent total or near-total thyroidectomy and RAI treatment in our hospital from January 2011 to July 2014. The BRAF(V600E) status of the primary lesions was determined and the patients were divided into two groups according to the presence of the mutation. Serological and imaging data were collected at a median follow-up of 2.34 years after RAI administration. Suppressed and stimulated thyroglobulin (Tg), Tg antibody, diagnostic whole-body scintigraphy, and other imaging examinations were used to assess clinical outcome, which was defined as excellent response, indeterminate response, biochemical incomplete response and structural incomplete response. The BRAF(V600E) mutation was observed in 153 of the 228 patients (67.1 %). The clinicopathological features did not differ bet...Continue Reading

References

Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jan 15, 2005·Thyroid : Official Journal of the American Thyroid Association·Laurence LeenhardtUNKNOWN Thyroid Cancer Committee
Mar 31, 2005·Annals of Surgery·Laura FalvoEnrico De Antoni
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Mingzhao XingPaul W Ladenson
Oct 6, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaFranco Keller
Jan 4, 2007·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasSteven I Sherman
Jun 15, 2007·Journal of Surgical Oncology·Yale D PodnosJoshua D I Ellenhorn
Sep 18, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ernest L Mazzaferri
Dec 20, 2007·Expert Review of Molecular Diagnostics·Marina N Nikiforova, Yuri E Nikiforov
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsey EnewoldSusan S Devesa
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Sep 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa M CaroniaManisha H Shah
Mar 27, 2012·The Medical Clinics of North America·Furio Pacini, Maria Grazia Castagna
Oct 23, 2012·Thyroid : Official Journal of the American Thyroid Association·Gregory W RandolphUNKNOWN American Thyroid Association Surgical Affairs Committee’s Taskforce on Thyroid Cancer Nodal Surgery
May 30, 2013·Thyroid : Official Journal of the American Thyroid Association·Jason S RadowskyAlexander Stojadinovic
Sep 18, 2013·Thyroid : Official Journal of the American Thyroid Association·Peter BartensteinJames Magner
Sep 21, 2013·World Journal of Surgery·Yasuhiro ItoAkira Miyauchi
Jan 7, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xin LiuXiaodong Liu
Oct 22, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mingzhao XingVlasta Sýkorová

❮ Previous
Next ❯

Citations

Aug 15, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yan-Qing LiuYan-Song Lin
Jul 3, 2021·International Journal of Molecular Sciences·Wojciech GierlikowskiMarta Kotlarek-Łysakowska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.