Noninvasive 1H/13C magnetic resonance spectroscopic imaging of the intratumoral distribution of temozolomide

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Yoshinori KatoD Artemov

Abstract

Among the primary reasons for failure of anticancer chemotherapy are insufficient drug delivery to the tumor because of inadequate tumor vascularization and/or the antivascular effects of chemotherapy. Thus, determining the spatial intratumoral distribution of anticancer agents by noninvasive methods such as MRI/MRSI is important for monitoring cancer chemotherapy. We therefore studied the distribution of the 13C-labeled anticancer agent temozolomide ([13C]TMZ) in MCF-7 tumor-bearing mice using 1H/13C MRSI. In phantom studies inverse 13C detection with heteronuclear multiple quantum coherence (HMQC) provided a 2.3-fold gain in signal-to-noise ratio (SNR) over direct nuclear overhauser effect (NOE)-enhanced 13C-MRS. This enabled detection of [13C]TMZ in the micromolar range. Three-dimensional (3D) maps of drug distribution with a nominal 2.5-mm isotropic resolution were obtained following intraperitoneal administration of [13C]TMZ, for a total dose of 200 mg/kg. The status of the blood supply of tumors was assessed by gadolinium (Gd)-enhanced dynamic MRI. Nonuniform distributions of the drug and the contrast agent were detected in the tumors. Although carbon-13 MRSI has an inherently low sensitivity for detection, the novel tech...Continue Reading

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Citations

Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Aleksandar DenicIstvan Pirko
Apr 14, 2010·Chemical Reviews·Kristine GlundeZaver M Bhujwalla
Apr 28, 2011·Nature Reviews. Clinical Oncology·Bruno Morgan
Jun 7, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Sebastian Kozerke, Sven Plein
Oct 15, 2013·International Journal of Nanomedicine·Fei-Fei TengJin-Ming Yu
Mar 24, 2011·Future Medicinal Chemistry·Britto S SandanarajNicolau Beckmann
Jul 17, 2010·Future Medicinal Chemistry·Marie-France PenetZaver M Bhujwalla
Mar 26, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Aisling M O'HalloranRose Anne Kenny
Oct 27, 2018·Histochemistry and Cell Biology·Rajender NandigamaErik Henke
Apr 25, 2007·NMR in Biomedicine·Venu RamanZaver M Bhujwalla
Jul 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ileana HancuRichard P Mallozzi
Jun 21, 2013·NMR in Biomedicine·Marie-France PenetZaver M Bhujwalla
Jan 7, 2015·Journal of the American Chemical Society·Hisatsugu YamadaTeruyuki Kondo

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