PMID: 8583865Jan 1, 1995Paper

Noninvasive 3D MR microscopy as a tool in pharmacological research: application to a model of rheumatoid arthritis

Magnetic Resonance Imaging
N BeckmannM Rudin

Abstract

Magnetic resonance microscopy (MRM) was applied to noninvasively image skeletal structures in the hindpaw of the live rat to characterize the progression of a heterologous type II collagen-induced arthritic process. Using a resonator, with optimized filling factor, three-dimensional (3D) gradient-echo images with voxel dimensions of 94 x 81 x 60 micron3 were acquired in 54.6 min. Three-dimensional MRM reduces the slice positioning problem, which is critical in longitudinal studies. Moreover, due to the much smaller slice thickness of images derived from 3D data sets, partial volume effects are less pronounced than in corresponding 2D images. Distinct pathomorphological changes associated with the collagen-induced arthritic process (e.g., increase of metatarsophalangeal joint space, and bone and cartilage erosion) could thus be analyzed under in vivo conditions.

References

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Citations

Nov 12, 2005·Clinical & Experimental Metastasis·Karen M GauvainKatherine Weilbaecher
Feb 25, 1998·Brain Research. Brain Research Protocols·R MonetteP Morley
Aug 5, 2000·Radiology·F Feldman
Oct 27, 2005·The British Journal of Radiology·Y-X J Wang
May 28, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nicolau BeckmannPetra Engelhardt
Apr 20, 2010·Journal of Synchrotron Radiation·Chang-Hyuk ChoiJong-Ki Kim
Dec 30, 2003·NMR in Biomedicine·P FaureJ-C Beloeil
Dec 5, 2018·Proceedings of the National Academy of Sciences of the United States of America·Karin M E AnderssonMaria I Bokarewa
Sep 10, 2011·Arthritis and Rheumatism·Karolina WartolowskaIrene Tracey
Oct 18, 2019·Antioxidants·Heloisa V Pereira-MarósticaAnacharis B Sá-Nakanishi
Aug 30, 2008·Drugs in R&D·Jorge RipollNicolau Beckmann

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