Noninvasive assessment of diastolic function in subjects with preserved left ventricular ejection fraction: usefulness of color kinetic imaging

Journal of Cardiac Failure
Yasuharu TakedaKazuhiro Yamamoto

Abstract

Noninvasive assessment of left ventricular (LV) diastolic function is not established in patients with preserved ejection fraction. We investigated a relation between diastolic function and diastolic wall dynamics. In the animal study, data were collected in hypertensive Dahl salt-sensitive rats, a diastolic heart failure (DHF) model (n = 35), and normotensive Dahl rats (n = 26). In the clinical study, echocardiography was conducted in 26 diabetic patients with normal ejection fraction and 10 age-matched controls. The diastolic index of color-encoded images (color kinesis diastolic index [CK-DI]) was calculated as the ratio of LV cavity area expansion during the first 30% of diastolic filling time to that during the whole diastolic filling period. In the DHF model, the E/A ratio of the transmitral flow velocity curves was pseudonormalized with the development of heart failure, but CK-DI was not. CK-DI, not E/A, was significantly and inversely correlated with the time constant of LV relaxation. Angiotensin receptor blocker improved LV relaxation in the DHF model and increased CK-DI, but not E/A. The diabetic patients showed lower CK-DI than the controls, although E/A was not different. Color-encoded imaging is useful in evaluati...Continue Reading

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Citations

Dec 20, 2011·European Heart Journal Cardiovascular Imaging·Kian Keong PohMalissa J Wood
Sep 28, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Satoshi OkayamaYoshihiko Saito
Feb 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhiro YamamotoToshiaki Mano
Feb 2, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiro AizawaKazuhiro Yamamoto
Nov 19, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mayu NishioKazuhiro Yamamoto
Jun 1, 2011·The International Journal of Cardiovascular Imaging·Samira BahrainyEdward A Gill
Jun 28, 2011·Journal of Cardiac Failure·Yasuharu TakedaKazuhiro Yamamoto
Feb 3, 2009·Journal of Cardiac Failure·Yasuharu TakedaKazuhiro Yamamoto
Mar 19, 2011·European Journal of Heart Failure·Yasuharu TakedaKazuhiro Yamamoto

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