Noninvasive assessment of the early progression of atherosclerosis in adolescents with Kawasaki disease and coronary artery lesions

Pediatrics
N NotoK Harada

Abstract

The severity of carotid arteriosclerosis, defined as increased intima-media thickness (IMT) visible with B-mode ultrasound, is correlated with risk factors for coronary heart disease. Little is known, however, about the relation of IMT, the stiffness of the common carotid artery, and the progression of atherosclerosis in children with Kawasaki disease (KD) and coronary artery lesions (CAL). We investigated the associations among total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride, TC/HDL-C, ApoE genotype, glycohemoglobin, IMT, and arterial stiffness by high resolution ultrasound in 20 adolescents with KD and CAL (age: 16.6 +/- 4.1 years, males: 60%) and 20 sex- and age-matched healthy controls (Cont). No significant differences were observed in the values of body mass index and blood pressure between the 2 groups. Also no significant differences were observed in the levels of TC, LDL-C, HDL-C, triglyceride, TC/HDL-C within normal values, or the allele frequency of Apo E4 between the 2 groups. However, the values of IMT, stiffness, and glycohemoglobin in patients with KD were significantly higher than those in Cont (0.53 +/- 0.07 vs 0.46 +/- 0.05 mm, P <...Continue Reading

Citations

Aug 4, 2005·Indian Journal of Pediatrics·Monesha Gupta-Malhotra, P Syamasundar Rao
Mar 20, 2013·Best Practice & Research. Clinical Rheumatology·Jan Willem Cohen Tervaert
Oct 9, 2012·Cardiology in the Young·Fátima F PintoMiguel Mota-Carmo
Jun 19, 2007·Cardiology in Review·Gary M SatouMichael H Gewitz
Mar 26, 2005·Journal of Paediatrics and Child Health·J RoyleN Curtis
Aug 11, 2006·Journal of Paediatrics and Child Health·Chee Wen Terence LimSwee Chye Quek
Nov 8, 2012·Experimental Diabetes Research·Laura J MarcoAnne-Louise Ponsonby
Jul 5, 2011·Arthritis Research & Therapy·Johan Frostegård
Apr 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Ryuji FukazawaShunichi Ogawa
Aug 21, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
May 3, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Satoru IwashimaTakehiko Ohzeki
Nov 16, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Amir H AshrafiBahig M Shehata
Feb 8, 2013·Cardiology in the Young·Masato OguriMasato Takahashi
Jul 21, 2014·The Journal of Pediatrics·Jonathan LinJane C Burns
Aug 9, 2013·Rheumatology International·Raghvendra Singh MeenaSurjit Singh
Oct 19, 2012·Current Opinion in Cardiology·Lori B DanielsJane C Burns
Sep 20, 2012·Journal of Hypertension·Erzsébet Valéria HidvégiAttila Cziráki
Oct 13, 2006·European Journal of Pediatrics·Taeyeun KimJoowon Lee
Mar 1, 2013·Pediatrics and Neonatology·Cedric ManlhiotBrian W McCrindle
Jun 14, 2013·The Journal of Pediatrics·Takamichi Ishikawa, Satoru Iwashima
Feb 18, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Nobutaka NotoHideo Mugishima
Jul 16, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·L M Prieto TatoJ T Ramos Amador
Oct 16, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Lori B Daniels, Jane C Burns
Dec 4, 2015·Yonsei Medical Journal·Kyu Yeun Kim, Dong Soo Kim
Aug 28, 2007·The Journal of Pediatrics·Elif Seda Selamet Tierney, Jane W Newburger
Aug 28, 2007·The Journal of Pediatrics·Robert Dalla PozzaHeinrich Netz
Aug 28, 2007·The Journal of Pediatrics·Brian W McCrindleKhosrow Adeli
Aug 18, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Reiki OoyanagiHiroyuki Tsutsumi
May 22, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Hideo FukunagaToshiaki Shimizu

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