Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives

Gastroenterology Research and Practice
Gianluca PellinoFrancesco Selvaggi

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences treatment outcome and survival. Notwithstanding the recent advances in multidisciplinary management and treatment of CRC, patients are still reluctant to undergo screening tests because of the associated invasiveness and discomfort (e.g., colonoscopy with biopsies). Moreover, the serological markers currently used for diagnosis are not reliable and, even if they were useful to detect disease recurrence after treatment, they are not always detected in patients with CRC (e.g., CEA). Recently, translational research in CRC has produced a wide spectrum of potential biomarkers that could be useful for diagnosis, treatment, and follow-up of these patients. The aim of this review is to provide an overview of the newer noninvasive or minimally invasive biomarkers of CRC. Here, we discuss imaging and biomolecular diagnostics ranging from their potential usefulness to obtain early and less-invasive diagnosis to their potential implementation ...Continue Reading

References

Oct 11, 1992·Annals of Surgery·B M EversJ C Thompson
Apr 11, 1992·Surgical Oncology·K YoshinagaJ C Thompson
Jan 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PaikC R King
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Jan 18, 1996·The New England Journal of Medicine·J E AllisonA L Adrain
Apr 10, 1997·Nature·C LengauerB Vogelstein
May 20, 1998·Journal of the National Cancer Institute·H J AndreyevP A Clarke
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·A Wells
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A de GramontA Bonetti
Sep 5, 2001·British Journal of Cancer·H J AndreyevN Urosevic
Jun 22, 2002·AJR. American Journal of Roentgenology·Revathy B IyerChusilp Charnsangavej
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Thierry LecomtePierre Laurent-Puig
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
May 27, 2003·International Journal of Cancer. Journal International Du Cancer·Daniel R NathansonPhilip B Paty
Oct 23, 2003·Endocrine Reviews·Robert P ThomasB Mark Evers
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guoren DengYoung S Kim
Apr 8, 2004·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Silvia SabbioniMassimo Negrini
May 15, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akishi OoiYoh Dobashi
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Nov 13, 2004·Clinical Chemistry·Luis J HerreraTony E Godfrey
Dec 24, 2004·The New England Journal of Medicine·Thomas F ImperialeUNKNOWN Colorectal Cancer Study Group
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PopatR S Houlston
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Piero BenattiGiovanni Lanza
Feb 2, 2006·Diseases of the Colon and Rectum·Edurne ArriolaJose R Germa-Lluch
Feb 9, 2006·Chemical Reviews·Ravi R IyerPaul L Modrich
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Helen I MeissnerSally W Vernon
Apr 14, 2006·Nature Reviews. Molecular Cell Biology·Josef Jiricny
Apr 19, 2006·Cancer Research·Astrid LièvrePierre Laurent-Puig
Jun 24, 2006·Nature Reviews. Cancer·Brian Bierie, Harold L Moses
Aug 1, 2006·Nature Genetics·Michael DewsAndrei Thomas-Tikhonenko
Sep 23, 2006·Developmental Biology·Baohong ZhangTodd A Anderson

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Citations

Nov 27, 2019·Intestinal research·Hyung-Hoon Oh, Young-Eun Joo
May 10, 2020·International Journal of Molecular Sciences·Anna SiskovaVeronika Vymetalkova
Jul 31, 2020·International Journal of Molecular Sciences·Olorunseun O OgunwobiAkinfemi Akingboye
Feb 24, 2020·Molecular Biology Reports·Muhammad Tarek Abdel GhafarAlzahraa A Allam
Jan 20, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Bhoomika SharmaNavneet Agnihotri
Jan 3, 2021·Cancer Genetics·Cemal Çağıl KoçanaSelçuk Sözer
Feb 4, 2021·International Journal of Molecular Sciences·Megha BhardwajHermann Brenner
Mar 7, 2021·International Journal of Molecular Sciences·Liting HuangSujie Zhu
Apr 11, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Shih-Hsin ChenAshley M Groves
May 27, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chongshun LiuYuqiang Li
Jun 3, 2021·Journal of Clinical Medicine·Gaetano GalloGiuseppe Sammarco
Jun 17, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Gaetano Gallo
Jul 3, 2021·Journal of Personalized Medicine·Bader AlmuzzainiMohammad Azhar Aziz
Jul 3, 2021·Journal of Clinical Medicine·Maria PanagopoulouEkaterini Chatzaki
Jul 30, 2021·World Journal of Gastrointestinal Oncology·Hande BeklenKazim Yalcin Arga
Jul 27, 2021·Nucleosides, Nucleotides & Nucleic Acids·Tayyebeh GhasemiParviz Asadi

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Methods Mentioned

BETA
biopsies
biopsy
PCR
flow cytometry
imaging technique
GTPase
xenografts
xenograft

Software Mentioned

TexRAD

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