PMID: 9444338Jan 28, 1998Paper

Noninvasive cerebral cooling in a swine model of cardiac arrest

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
S C TadlerJ J Menegazzi

Abstract

Mild cerebral hypothermia improves neurologic outcome in animals resuscitated from cardiac arrest. This study examined whether one practical external cooling method, i.e., local application of ice to the heads and necks of swine, during resuscitation induces cerebral cooling. Local external cerebral cooling was examined in a prospective laboratory investigation using 24 female swine in a model of cardiac arrest. The swine were randomized into hypothermia and normothermia groups. Intracerebral temperature was measured in the parietal cortex. Eight minutes after induction of ventricular fibrillation, chest compressions and mechanical ventilation were initiated. The hypothermia group was treated with 1,500 mL of ice in plastic bags applied to the head and neck, while the normothermia group received no extra interventions. Data were analyzed using repeated-measures ANOVA. In the normothermia group, there was no significant change in nasopharyngeal (-0.8 +/- 0.6 degree C), intracerebral (-0.6 +/- 0.8 degree C), or esophageal (-0.2 +/- 0.6 degree C) temperatures during 20 minutes of resuscitation. However, in the hypothermia group, application of ice during resuscitation significantly reduced nasopharyngeal (-2.9 +/- 1.4 degrees C), ...Continue Reading

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Citations

Feb 14, 2002·Resuscitation·Clifton W CallawayEric Brader
Oct 29, 2004·Critical Care Medicine·Menekhem M ZvimanHenry R Halperin
Oct 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K MoriE W Dickson
Apr 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K MoriE W Dickson
Apr 17, 2004·Journal of Neurosurgery·Huan WangDavid Wang
Mar 13, 2014·The Journal of Comparative Neurology·Dasa DolezalovaMartin Marsala
Jan 12, 2000·Pediatric Clinics of North America·M D Patterson
Jul 27, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Brian J D'CruzClifton W Callaway
May 29, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maria ErecinskaIan A Silver

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