Noninvasive determination of cardiac output in a model of acute lung injury

Critical Care Medicine
J H ArnoldL W Arnold

Abstract

To examine the utility of single breath CO2 analysis as a noninvasive measure of cardiac output in a model of acute lung injury. An animal laboratory in a university-affiliated medical center. A prospective, animal cohort study comparing 21 parameters derived from single breath CO2 analysis with cardiac output determined by an ultrasonic flow probe. Six adult sheep with saline lavage-induced acute lung injury. Animals were treated with repetitive saline lavage to achieve a uniform degree of acute lung injury (PaO2 of < 100 torr [< 13.32 kPa] on an FIO2 of 1.0). Cardiac output was manipulated by successive injections of an hydraulic constrictor placed around the inferior vena cava and measured using an ultrasonic flow probe. Twenty-one derived components of the CO2 expirogram were evaluated as predictors of cardiac output. Thirty-eight measurements of cardiac output were available for comparison with derived variables from the CO2 expirogam. Stepwise linear regression identified four variables for the equation predicting cardiac output: a) PaO2/FIO2 ratio; b) the angle between the slope lines for phases II and III divided by the tidal volume; c) mixed expired CO2 tension; and d) physiologic deadspace to tidal volume ratio. The m...Continue Reading

References

Mar 1, 1970·Journal of Applied Physiology·J P ClausenJ Trap-Jensen
Mar 1, 1968·Journal of Applied Physiology·G MuiesanE Petz
Jun 1, 1980·Acta Anaesthesiologica Scandinavica·B LachmannJ Vogel
Jan 1, 1996·Critical Care Medicine·J H ArnoldL W Arnold
Oct 1, 1996·Critical Care Medicine·J H ArnoldL W Arnold

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Citations

Mar 4, 2000·The Journal of Emergency Medicine·R M Rodriguez, K A Berumen
Jun 8, 2001·Critical Care Medicine·J H Arnold
May 16, 2002·Current Opinion in Pediatrics·Shane M Tibby, Ian A Murdoch

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