Noninvasive determination of regional myocardial perfusion with first-pass magnetic resonance (MR) imaging

Academic Radiology
Takahito NakajimaKeigo Endo

Abstract

To develop a method to provide absolute values of regional myocardial perfusion by means of color maps, and to determine myocardial perfusion reserve using magnetic resonance imaging during the first pass of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). The study population consisted of five patients with hypertrophic cardiomyopathy, two with dilated cardiomyopathy, four with coronary artery disease, and one with normal coronary arteries who presented with mildly abnormal electrocardiogram findings. For each heartbeat, six continuous slices were acquired during the first pass of Gd-DTPA (0.05 mmol/kg body weight) before and during adenosine triphosphate (ATP) **stress using an electrocardiogram-triggered fast low-angle shot (FLASH) sequence on a 1.5-T magnetic resonance unit. Myocardial perfusion images were created and displayed by means of a color scale. The parameters were calculated pixel by pixel, using the upslope method. Myocardial perfusion reserve was then calculated, as the quotient of myocardial perfusion during ATP stress and perfusion before ATP stress. Myocardial perfusion during ATP stress in patients with normal coronary arteries (n = 1) or after successful percutaneous coronary intervention (n = 2) ...Continue Reading

References

Mar 1, 1990·Radiology·D J AtkinsonR R Edelman
Apr 8, 1999·Journal of the American College of Cardiology·J H CullenN J Samani
Aug 21, 2002·Academic Radiology·Yoshito TsushimaKeigo Endo
Sep 12, 2003·The New England Journal of Medicine·Franco CecchiPaolo G Camici

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