Noninvasive diagnosis of fibrosis in chronic liver disease

Expert Review of Molecular Diagnostics
Ralf Lichtinghagen, Matthias J Bahr

Abstract

Laboratory tests for the noninvasive diagnosis of liver fibrosis were studied extensively in the past. However, no test is yet accepted to replace liver biopsy as the gold standard. The establishment of widely accepted semiquantitative histologic scoring systems for the grading and staging of chronic liver disease (e.g., Ishak, Metavir and Scheuer) was paralleled by a significant upturn of research in circulating markers of liver fibrosis. We are now experiencing the renaissance of standard clinical chemistry markers, which are assembled to multiparameter scores (e.g., aspartate aminotransferase-to-platelet ratio index, FibroTest, Forns' index). These scores still require comprehensive evaluation in comparison with histology. Better understanding of the pathophysiology of liver fibrosis provided new options regarding circulating markers of hepatic matrix metabolism (e.g., hyaluronic acid, laminin, matrix metalloproteinase-2, aminoterminal propeptide of procollagen type III and tissue inhibitors of metalloproteinases-1). Several promising studies have been published to date. Thus, a redefinition of the role of liver biopsy is expected in the foreseeable future.

References

Nov 1, 1991·Journal of Hepatology·P J Scheuer
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jun 1, 1996·Gastrointestinal Endoscopy·J PoniachikE R Schiff
Aug 7, 1998·Digestion·A Hayasaka, H Saisho
Jul 15, 2000·Seminars in Liver Disease·T PoynardP Opolon
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Oct 3, 2002·Gastroenterology·Richard M Green, Steven Flamm
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominique ThabutThierry Poynard
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keyur PatelJohn G McHutchison
Jun 13, 2003·Genome Biology·Robert P T SomervilleSuneel S Apte
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edoardo Giannini, Roberto Testa
Apr 16, 2004·Seminars in Liver Disease·Maria Guido, Massimo Rugge
Apr 20, 2004·Journal of Hepatology·Valeer J Desmet, Tania Roskams
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Archana SudJacob George
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fabrice LainéYves Deugnier

❮ Previous
Next ❯

Citations

Apr 9, 2005·Current Opinion in Gastroenterology·Albert J Czaja
Jun 26, 2009·World Journal of Gastroenterology : WJG·Fei WangYing-Jie Sun
Sep 13, 2011·Scandinavian Journal of Gastroenterology·Timo RathReinhart Zachoval
Feb 23, 2005·Expert Review of Molecular Diagnostics·Thierry PoynardVlad Ratziu
Sep 30, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Valerio NobiliMassimo Pinzani
Aug 2, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CorradiUNKNOWN Bologna Liver Transplantation Group
Dec 18, 2007·Alimentary Pharmacology & Therapeutics·E Gómez-DominguezR Moreno-Otero
Mar 4, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Claus NiederauAndreas Thiel
Apr 25, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Emanuela TestaRoberto Testa
Aug 17, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Helen LydatakisIoannis Diamantis
Aug 5, 2006·Alimentary Pharmacology & Therapeutics·E Gómez-DomínguezR Moreno-Otero
Mar 26, 2013·Journal of Hepatology·Ralf LichtinghagenMatthias J Bahr
Feb 19, 2008·American Journal of Obstetrics and Gynecology·Pauliina TuomikoskiOlavi Ylikorkala
Jun 5, 2012·International Journal of Cardiology·Ausra KavoliunieneGiedre Cesnaite
Aug 20, 2010·Memórias do Instituto Oswaldo Cruz·Clarice Neuenschwander Lins de MoraisSilvia Maria Lucena Montenegro
Jun 10, 2010·Journal of Pediatric Gastroenterology and Nutrition·Sang Yong KimHong Koh
Jan 27, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroko IijimaShuhei Nishiguchi
Nov 9, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Ifeoluwa T OyeyemiAdekunle A Bakare
Jun 27, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Limei XieXiaowen Zhang
Aug 3, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xingshun QiXiaozhong Guo
Jan 27, 2006·World Journal of Gastroenterology : WJG·N DioguardiF Grizzi
Jan 1, 2008·Substance Abuse : Research and Treatment·Thomas F KresinaH Westley Clark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Xavier FornsJuan Rodés
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Chun-Tao WaiAnna S-F Lok
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Doris Nguyen, Jayant A Talwalkar
© 2021 Meta ULC. All rights reserved