Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience

Open Forum Infectious Diseases
Jenna RossoffWilliam J Muller

Abstract

Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.

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Citations

Jan 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Esther Babady
Jan 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine A HoganNiaz Banaei
Mar 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine A HoganNiaz Banaei
Mar 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J Muller, Sonali Chaudhury
Jun 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A BrandaNira R Pollock
Feb 8, 2020·Current Infectious Disease Reports·Erin H Graf, Preeti Pancholi
Mar 20, 2021·Expert Review of Molecular Diagnostics·Lluís Moragues-SolanasJustin O'Grady
Jan 8, 2021·The Pediatric Infectious Disease Journal·Rachel K ToNicole G Coufal
Jun 15, 2021·Frontiers in Molecular Biosciences·Lili WangWenjuan Wu
Jun 24, 2021·Medicine·Thomas SchmochThorsten Brenner
Jun 28, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Rachel Martin-BlaisNava Yeganeh
Apr 25, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Madiha FidaRobin Patel
Jul 23, 2021·The Journal of Bone and Joint Surgery. American Volume·Adriana P EcheverriaLaura T Donlin
Dec 11, 2021·Hematology·Kirsten M Williams

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Methods Mentioned

BETA
bronchoalveolar
biopsy

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