Noninvasive differentiation of meningiomas from other brain tumours using combined 111Indium-octreotide/99mtechnetium-DTPA brain scintigraphy

Acta neurochirurgica
A BarthR W Seiler

Abstract

We have studied prospectively 47 patients with CNS tumours including 16 meningiomas and 33 other tumours using combined 111In-octreotide and 99mTc-DTPA brain scintigraphy. 111In-octreotide scintigraphy was used to image somatostatin receptors (SSR) and 99mTc-DTPA scintigraphy was used to assess the integrity of the blood-brain barrier (BBB). A total of 32 tumours (65%) were detected. All SSR positive tumours also had positive 99mTc-DTPA scans and all SSR negative tumours were negative on 99mTc-DTPA scans. Among the tumours located outside the BBB, all meningiomas and two out of six schwannomas were positive on combined SSR/99mTc-DTPA scintigraphy. Among the tumours located inside the BBB, seven out of nine gliomas grade I-III were negative, whereas all glioblastomas were positive. Other positive tumours included one malignant non-Hodgkin lymphoma and two cerebral metastases. SSR scintigraphy alone was non-specific in the diagnosis of meningiomas, as 16 non-meningiomatous tumours also had positive SSR scans probably due to a breakdown of the BBB (excluding the malignant lymphoma). Measuring the tumour-to-background ratio on SSR scans improved specificity, but sensitivity was decreased below 70% because some meningiomas were only...Continue Reading

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Citations

Feb 11, 2012·Journal of Neurology·Ronit GiladMordechai Loyberboim
Nov 20, 2009·Radiation Oncology·Barbara GehlerUte Ganswindt
May 5, 2011·Journal of Biomedicine & Biotechnology·Fan-Lin KongDavid J Yang
Jun 9, 2009·Ophthalmology·Peerooz SaeedRoelof J Bennink
Nov 27, 2007·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·I-Chien WeiDavid J Yang
Jan 15, 2005·Journal of Receptor and Signal Transduction Research·Alex N EberleSylvie Froidevaux
Oct 19, 2005·Cerebrovascular Diseases·Yair LamplMordechai Lorberboym
Feb 1, 2005·The British Journal of Radiology·M J Acosta-GómezA de la Riva-Aguilar
Jul 20, 2006·Journal of Neuro-oncology·Narendra NathooGene H Barnett

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