Noninvasive estimation of the aorta input function for measurement of tumor blood flow with

IEEE Transactions on Medical Imaging
H WatabeR E Carson

Abstract

Quantitative measurement of tumor blood flow with [15O]water can be used to evaluate the effects of tumor treatment over time. Since quantitative flow measurements require an input function, we developed the profile fitting method (PFM) to measure the input function from positron emission tomography images of the aorta. First, a [11C]CO scan was acquired and the aorta region was analyzed. The aorta diameter was determined by fitting the image data with a model that includes scanner resolution, the measured venous blood radioactivity concentration, and the spillover of counts from the background. The diameter was used in subsequent fitting of [15O]water dynamic images to estimate the aorta and background radioactivity concentrations. Phantom experiments were performed to test the model. Image quantification biases (up to 15%) were found for small objects, particularly for those in a large elliptical phantom. However, the bias in the PFM concentration estimates was much smaller (2%-6%). A simulation study showed that PFM had less bias and/or variability in flow parameter estimates than an ROI method. PFM was applied to human [11C]CO and [15O]water dynamic studies with left ventricle input functions used as the gold standard. PFM ...Continue Reading

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Citations

Feb 14, 2007·Annals of Nuclear Medicine·Hiroshi WatabeMiho Shidahara
May 7, 2008·European Journal of Nuclear Medicine and Molecular Imaging·N KudomiP Iozzo
Jun 16, 2009·European Journal of Nuclear Medicine and Molecular Imaging·N KudomiP Iozzo
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Apr 1, 2007·PET Clinics·M'hamed Bentourkia, Habib Zaidi
Oct 19, 2010·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Xiujuan ZhengDagan Feng
Oct 26, 2005·Nuclear Medicine and Biology·Richard LaforestMichael J Welch
Apr 24, 2004·Physics in Medicine and Biology·Marie-Claude AsselinClaude Nahmias
Aug 7, 2012·Nuclear Medicine Communications·Gaber KomarHeikki Minn
Jul 13, 2016·Physics in Medicine and Biology·Nobuyuki KudomiYoshihiro Nishiyama
Dec 6, 2014·Physics in Medicine and Biology·Y JianR E Carson

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