Noninvasive evaluation of skeletal muscle mitochondrial capacity with near-infrared spectroscopy: correcting for blood volume changes.

Journal of Applied Physiology
Terence E RyanKevin K Mccully

Abstract

Near-infrared spectroscopy (NIRS) is a well-known method used to measure muscle oxygenation and hemodynamics in vivo. The application of arterial occlusions allows for the assessment of muscle oxygen consumption (mVo(2)) using NIRS. The aim of this study was to measure skeletal muscle mitochondrial capacity using blood volume-corrected NIRS signals that represent oxygenated hemoglobin/myoglobin (O(2)Hb) and deoxygenated hemoglobin/myoglobin (HHb). We also assessed the reliability and reproducibility of NIRS measurements of resting oxygen consumption and mitochondrial capacity. Twenty-four subjects, including four with chronic spinal cord injury, were tested using either the vastus lateralis or gastrocnemius muscles. Ten healthy, able-bodied subjects were tested on two occasions within a period of 7 days to assess the reliability and reproducibility. NIRS signals were corrected for blood volume changes using three different methods. Resting oxygen consumption had a mean coefficient of variation (CV) of 2.4% (range 1-32%). The recovery of oxygen consumption (mVo(2)) after electrical stimulation at 4 Hz was fit to an exponential curve, which represents mitochondrial capacity. The time constant for the recovery of mVo(2) was reprod...Continue Reading

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Citations

May 25, 2013·European Journal of Applied Physiology·Melissa Lynn EricksonKevin K McCully
May 29, 2013·European Journal of Applied Physiology·Jared R FletcherBrian R Macintosh
Jul 3, 2013·Archives of Physical Medicine and Rehabilitation·Terence E RyanKevin K McCully
Apr 29, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·William M SouthernKevin McCully
Dec 8, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kristine R PolleyKevin McCully
Dec 10, 2015·Human Movement Science·Knut SkoverengMireille van Beekvelt
Dec 29, 2015·Biochimica Et Biophysica Acta·Matthew D Campbell, David J Marcinek
Mar 13, 2014·Muscle & Nerve·Terence E RyanKevin K Mccully
Mar 12, 2015·Experimental Physiology·Melissa L EricksonRyan A Harris
Oct 8, 2014·Muscle & Nerve·Pietro CaliandroPaolo M Rossini
Apr 30, 2016·European Journal of Applied Physiology·Knut SkoverengMireille C P van Beekvelt
Nov 7, 2016·Heart Failure Reviews·Sophia Z Liu, David J Marcinek
Dec 22, 2016·Muscle & Nerve·Hannah M BossieKevin K McCully
Jun 14, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Mary Ann HarpDeborah Backus
Aug 29, 2018·European Journal of Preventive Cardiology·Jonathan R MurrowKevin K McCully
Apr 7, 2016·Journal of Biomedical Optics·Thomas B WillinghamKevin K McCully
Mar 8, 2019·Journal of Applied Physiology·Thomas J Barstow
Mar 12, 2019·Circulation·Anupam A KumarJulio A Chirinos
May 15, 2013·Medicine and Science in Sports and Exercise·Terence Edward RyanKevin K McCully
Jun 10, 2019·European Journal of Applied Physiology·Bart LagerwaardArie G Nieuwenhuizen
Nov 1, 2016·Journal of Applied Physiology·Jane A Kent, Liam F Fitzgerald
Jun 3, 2017·Journal of Applied Physiology·Daniel D ShillNathan T Jenkins
Dec 19, 2012·Medicine and Science in Sports and Exercise·Jared Todd BrizendineKevin K McCully
Aug 10, 2020·Experimental Physiology·Cristiane Cenachi CoelhoDanielle Aparecida Gomes Pereira
Jul 24, 2020·Journal of Applied Physiology·Austin T BeeverMartin J MacInnis
Sep 24, 2020·The Journal of Physiology·Paul AnsdellStuart Goodall

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