Noninvasive evaluation of wall shear stress on retinal microcirculation in humans

Investigative Ophthalmology & Visual Science
Taiji Nagaoka, Akitoshi Yoshida

Abstract

To evaluate wall shear stress (WSS) on retinal microcirculation noninvasively. Retinal vessel diameter (D) and mean centerline blood velocity (V(max, mean)) were measured in the retinal arterioles and venules at first- and second-order branches in 13 subjects using laser Doppler velocimetry (LDV). Retinal blood flow (RBF) and wall shear rate (WSR) were calculated using these two parameters. Blood viscosity at the calculated shear rate was also measured using a cone-plate viscometer. WSS was calculated as the product of the WSR and the blood viscosity. In the first-order branches, the averaged D, V(max, mean), RBF, and WSR(mean) were 108 +/- 13 microm, 41 +/- 10 mm/s, 11 +/- 4 microL/min, and 1539 +/- 383 s(-1) in the arterioles and 147 +/- 13 microm, 23 +/- 3 mm/s, 12 +/- 4 microL/min, and 632 +/- 73 s(-1) in the venules, respectively. The apparent blood viscosities at the measured shear rates were 3.5 +/- 0.3 centipoise (cP) in the arterioles and 3.8 +/- 0.4 cP in the venules. Therefore, the averaged WSS was 54 +/- 13 dyne/cm2 in the arterioles and 24 +/- 4 dyne/cm2 in the venules. The WSS in the second-order arterioles was significantly lower than that in the first-order branches (P = 0.002), but the WSS in the first-order ve...Continue Reading

Citations

Jun 15, 2012·Japanese Journal of Ophthalmology·Motofumi KawaiAkitoshi Yoshida
Feb 2, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Elishai EzraYaakov Nahmias
Sep 8, 2011·Tissue Engineering. Part a·Mandy B EschTracy Stokol
Jul 13, 2013·Investigative Ophthalmology & Visual Science·Julia ArcieroGiovanna Guidoboni
May 3, 2014·Microvascular Research·Antony ThomasYaling Liu
Mar 1, 2014·Brain : a Journal of Neurology·Ian J C MacCormickSimon P Harding
Aug 1, 2014·Journal of the Royal Society, Interface·Miguel O BernabeuPeter V Coveney
Dec 15, 2015·Medical Engineering & Physics·Rosa D'ApolitoStefano Guido
Oct 25, 2011·American Journal of Ophthalmology·Sapna GangaputraUNKNOWN Studies of the Ocular Complications of AIDS Research Group
Jul 27, 2010·Optometry : Journal of the American Optometric Association·Shelly Adams, Mark Ostermeier
May 19, 2010·Microvascular Research·Aristotle G KoutsiarisEvagelia Tsironi
Dec 4, 2009·Biomaterials·Phapanin CharoenpholOmolola Eniola-Adefeso
Aug 12, 2009·Experimental Eye Research·Taiji NagaokaAkitoshi Yoshida
Jan 28, 2009·Survey of Ophthalmology·Cong SunTien Y Wong
May 2, 2008·Progress in Retinal and Eye Research·Constantin J PournarasEinar Stefansson
Dec 21, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Paul R ClarkJordan S Pober
Apr 5, 2013·Acta Ophthalmologica·Anne WillerslevMichael Larsen
Oct 10, 2015·IEEE Transactions on Medical Imaging·Maziyar M KhansariMahnaz Shahidi
Sep 6, 2015·Blood Reviews·Philippe ConnesSamir K Ballas
Apr 19, 2012·Current Eye Research·Kenji SogawaAkitoshi Yoshida
Mar 23, 2011·Nitric Oxide : Biology and Chemistry·Pinar UlkerOguz K Baskurt
Oct 27, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Emine Kilic-ToprakMelek Bor-Kucukatay
Jun 25, 2013·Microvascular Research·Aristotle G Koutsiaris
Apr 8, 2017·Scientific Reports·Maziyar M KhansariMahnaz Shahidi
Sep 29, 2017·Critical Reviews in Biotechnology·Inês B GomesManuel Simões
Feb 21, 2016·Annals of Biomedical Engineering·Aristotle G Koutsiaris
Oct 4, 2019·Scandinavian Journal of Medicine & Science in Sports·Lukas StreeseHenner Hanssen
Feb 2, 2018·PloS One·Evelyn Li Min TaiIsmail Shatriah
May 30, 2019·Biomechanics and Modeling in Mechanobiology·Joseph RebhanBarry J Doyle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.