Noninvasive eye localization in ocular proton therapy through optical eye tracking: A proof of concept

Medical Physics
Riccardo ViaJan Hrbacek

Abstract

Over the last four decades, Ocular Proton Therapy has been successfully used to treat patients affected by intraocular lesions. For this, treatment geometry verification is routinely performed using radiographic images to align a configuration of fiducial radiopaque markers implanted on the sclera outer surface. This paper describes the clinical application of an alternative approach based on optical eye tracking for three-dimensional noninvasive and automatic eye localization. An experimental protocol was designed to validate the optical-based eye referencing against both radiographic imaging system and the clinically used EYEPLAN treatment planning system. The eye tracking system (ETS) was installed in the OPTIS 2 treatment room at PSI to acquire eye motions during the treatment of nine patients. The pupil position and the cornea curvature center were localized by segmenting the pupil contour and corneal light reflections on the images acquired by a pair of calibrated optical cameras. After calibration of the ETS, a direct comparison of radiopaque markers position, and consequentially eye position and orientation, provided by the ETS, radiographs and EYEPLAN was performed. Nineteen out of thirty total monitored fractions were...Continue Reading

References

May 1, 1983·Medical Physics·M Goitein, T Miller
Oct 1, 1993·The British Journal of Radiology·D E BonnettT E Saxton
May 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·U KellnerM H Foerster
May 18, 1999·Archives of Ophthalmology·K GündüzL W Brady
Sep 7, 1999·International Journal of Radiation Oncology, Biology, Physics·A CourdiP Chauvel
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·M FussJ D Slater
Oct 2, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K DieckmannR Pötter
Dec 10, 2002·Archives of Ophthalmology·Evangelos GragoudasKathleen M Egan
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Emmanuel EggerGudrun Goitein
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Karin MullerPeter Levendag
Jul 9, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stefan HöchtWolfgang Hinkelbein
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Bertil DamatoR Douglas Errington
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Damien C WeberRaymond Miralbell
Apr 11, 2006·Radiation Protection Dosimetry·F MourtadaW Newhauser
Jun 10, 2006·IEEE Transactions on Bio-medical Engineering·Elias Daniel Guestrin, Moshe Eizenman
Oct 27, 2006·Investigative Ophthalmology & Visual Science·Evangelos S Gragoudas
May 15, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dag Rune OlsenInger Natvig Norderhaug
Aug 5, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A Kacperek
Jul 27, 2012·Medical Physics·Dongho ShinSung Yong Park
Aug 8, 2012·International Journal of Radiation Oncology, Biology, Physics·Michael B RüegseggerJens H Kowal
Sep 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Roman DunavoelgyiKarin Dieckmann
Jan 1, 2014·Brachytherapy·UNKNOWN American Brachytherapy Society - Ophthalmic Oncology Task Force. Electronic address: paulfinger@eyecancer.com, UNKNOWN ABS – OOTF Committee
Sep 20, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·C MaschiJ-P Caujolle
Dec 15, 2015·IEEE Transactions on Bio-medical Engineering·Stephan WyderPhilippe C Cattin
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Jan HrbacekDamien C Weber

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