Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Asian Practice: Perspectives for Surgical Pathology and Cytopathology

Endocrine Pathology
Andrey BychkovKennichi Kakudo

Abstract

The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was initiated and promoted by pathologists. Recent Asian studies added new knowledge to the existing literature to aid a better understanding of NIFTP. Our original data and the results of a meta-analysis suggest that the initial rate of NIFTP has been overestimated, averaging 9.1% (95% confidence interval [CI] 6.0-12.7%) of all papillary thyroid cancers worldwide. The incidence of NIFTP in the Asian population (1.6%, 95% CI 0.9-2.5%; 7 studies) is significantly lower than that reported in the non-Asian series (13.3%, 95% CI 9.0-18.3%; 18 studies). Such difference could be attributed to various perceptions of histological diagnostic thresholds, different nature of papillary thyroid carcinoma, and different approaches in the management of thyroid nodules. The active surveillance for indeterminate nodules and NIFTP, largely represented in the indeterminate cytologic categories, promoted by Japanese institutions establishes a new paradigm to reduce overtreatment of these patients. The lower prevalence of NIFTP in the Asian series indicates a low impact on the risk of malignancy in cytopathology, as it was demonstrated in our or...Continue Reading

References

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Citations

Sep 7, 2018·Journal of Immunoassay & Immunochemistry·Asmaa Gaber AbdouSara Fahmy
Mar 27, 2019·Endocrine-related Cancer·Pedro Weslley Rosario, Gabriela Franco Mourão
Jan 19, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Huy Gia VuongTetsuo Kondo
Dec 12, 2018·Pathology International·Kennichi KakudoChan Kwon Jung
Oct 23, 2020·The Tohoku Journal of Experimental Medicine·Francesca MalettaMauro Papotti
Dec 4, 2020·American Journal of Clinical Pathology·Huy Gia VuongAndrey Bychkov
Dec 12, 2020·Journal of Clinical Laboratory Analysis·Faiza A RashidSyed Sameer Aga
Mar 9, 2021·Endocrinology and Metabolism·Chan Kwon JungKennichi Kakudo
May 30, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·David N PollerPierpaolo Trimboli
Apr 23, 2021·Genes & Cancer·Artur KuchareczkoAldona Kowalska
Dec 18, 2021·Thyroid : Official Journal of the American Thyroid Association·Vikas MehtaGregory W Randolph

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Methods Mentioned

BETA
surgical resection
biopsy

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