Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Epidemiology and Long-Term Outcomes in a Strictly Defined Cohort.

Thyroid : Official Journal of the American Thyroid Association
Rainjade ChungFrederick Thurston Drake

Abstract

Background: A subset of encapsulated/circumscribed follicular variant of papillary thyroid carcinoma (FVPTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in 2016 to reduce overtreatment of a low-risk tumor. Study objectives were to describe the epidemiology and long-term outcomes of NIFTP in a high-volume, urban, tertiary referral center. Methods: Among patients enrolled in the Boston Medical Center (BMC) Thyroid Cancer Registry, 110 cases of FVPTC underwent index thyroid surgery at BMC between 2000 and 2016. Historically, BMC pathologists assess all malignant nodules using sections ≤0.3 cm with evaluation of the entire nodule and capsule. After review of pathology reports to identify potential NIFTPs, slides were rereviewed using criteria established by the NIFTP Working Group in 2016 and 2018. We evaluated interobserver reliability using Cohen's Kappa coefficient. Results: Among 110 FVPTCs, 15 (13%) met NIFTP criteria; 11 women and 4 men, age range 31-64 (mean 47.5) years. Mean tumor diameter was 1.7 cm (compared with 2.2 cm for FVPTC). Among NIFTP cases, there were no lymph node metastases, distant metastases, or tumor recurrences. All NIFTP cases were American Thyr...Continue Reading

References

Nov 1, 2002·The American Journal of Surgical Pathology·Mitsuyoshi HirokawaKennichi Kakudo
Sep 17, 2004·The American Journal of Surgical Pathology·Ricardo V LloydMarick E Lae
Nov 5, 2013·The Journal of Clinical Endocrinology and Metabolism·Bert DelvouxAndrea Romano
Nov 4, 2016·Endocrine-related Cancer·Pedro Weslley RosarioMaria Regina Calsolari
Feb 1, 2017·Thyroid : Official Journal of the American Thyroid Association·Bin XuRonald A Ghossein
May 10, 2017·Thyroid : Official Journal of the American Thyroid Association·Andrey BychkovKennichi Kakudo

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Citations

Nov 5, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Jared C DublinBabak Givi

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Methods Mentioned

BETA
dissections
dissection

Software Mentioned

ThyroCARE

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