PMID: 11906265Mar 22, 2002Paper

Noninvasive imaging of peripherally injected Alzheimer's disease type synthetic A beta amyloid in vivo

Bioconjugate Chemistry
Jeffrey R MarshallJ E Maggio

Abstract

The pathological hallmark of Alzheimer's disease (AD) is accumulation in the brain of amyloid composed of the 40-mer peptide A beta. Many fundamental questions about the biology of (AD) remain unanswered because there is currently no method of quantifying A beta amyloid in vivo. A noninvasive method of detecting and quantifying A beta amyloid in vivo would have wide application for the premortem diagnosis of AD and the efficient evaluation of candidate therapeutics aimed at inhibiting the formation and growth of A beta amyloid. Taking advantage of the extraordinarily high affinity of A beta for itself, we have synthesized an N'-terminal diethylenetriaminepentaacetic acid (DTPA) derivative of A beta possessing the kinetic activity and specificity for A beta amyloid desired of a probe to be used for noninvasive imaging. DTPA-A beta(3-40) is readily labeled with (111)InOAc(3) to yield a stable probe with exquisite specificity for naturally occurring and synthetic A beta amyloid in vitro. Moreover, (111)In-DTPA-A beta(3-40), administered intravascularly can specifically deposit onto and label previously injected synthetic A beta amyloid and be imaged in vivo with a gamma camera. The present results demonstrate the design, synthesis...Continue Reading

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Citations

Sep 1, 2009·Brain Imaging and Behavior·Michelle T Fodero-TavolettiVictor L Villemagne
Aug 12, 2008·Molecular Neurobiology·Victor L VillemagneChristopher C Rowe
Jun 30, 2006·Journal of Neurochemistry·Colin L MastersVictor L Villemagne
Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Victor L VillemagneC L Masters
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Brian J BacskaiBradley T Hyman
Jul 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Youssef Zaim WadghiriDaniel H Turnbull
Feb 22, 2005·Nuclear Medicine Communications·Sanjeet Pakrasi, John T O'Brien

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