Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography.

Biomedical Optics Express
Bahar DavoudiAlex Vitkin

Abstract

A spectral domain optical coherence tomography (SD-OCT) system and an oral imaging probe have been developed to visualize the microstructural morphology and microvasculature in the human oral cavity. Structural OCT images of ex vivo pig oral tissues with the histology of the same sites were acquired and compared for correlations. Structural in vivo OCT images of healthy human tissue as well as a pathologic site (ulcer) were obtained and analyzed based on the results of the ex vivo pig study, drawing on the similarity between human and swine oral tissues. In vivo Doppler and speckle variance OCT images of the oral cavity in human volunteers were also acquired, to demonstrate the feasibility of microvascular imaging of healthy and pathologic (scar) oral tissue.

References

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Citations

Jul 24, 2015·Biomedical Optics Express·Anthony M D LeePierre Lane
Jul 13, 2017·Journal of Biophotonics·Mitsuro SugitaAlex Vitkin
Nov 21, 2013·World Journal of Gastrointestinal Endoscopy·Mohammad S MahmudVictor Xd Yang
Jun 10, 2014·Physiological Measurement·John Allen, Kevin Howell
Dec 20, 2019·Tissue Engineering. Part B, Reviews·Binita ShresthaEric M Brey
Apr 27, 2020·Lasers in Medical Science·Zihan YangYanmei Liang
May 10, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Enrica GentileAlberta Lucchese
Jan 15, 2021·Lasers in Surgery and Medicine·Zihan YangYanmei Liang
Jan 12, 2021·Journal of Pharmaceutical Sciences·Constantin ItinAmnon Hoffman

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Software Mentioned

MATLAB
svOCT
ZEMAX
LabVIEW

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