Noninvasive Liver Assessment in Adult Patients With Fontan Circulation Using Acoustic Radiation Force Impulse Elastography and Hepatic Magnetic Resonance Imaging

World Journal for Pediatric & Congenital Heart Surgery
Francisco Buendía-FuentesL Martínez-Dolz

Abstract

Patients who have undergone the Fontan procedure are at risk of developing hepatic dysfunction. However, broad recommendations regarding liver monitoring are limited. The purpose of this study was to characterize the frequency of liver disease in adult Fontan patients using multimodality imaging (hepatic magnetic resonance imaging [MRI], acoustic radiation force impulse [ARFI] elastography, or hepatic ultrasound). In a prospective cross-sectional analysis of adult patients palliated with a Fontan procedure, hepatic MRI, ARFI, and hepatic ultrasound were used to assess for liver disease. The protocol compared (1) varying prevalence of liver disease based on each imaging technique, (2) agreement between different techniques, and (3) association between noninvasive imaging diagnosis of liver disease and clinical variables, including specific liver disease biomarkers. Thirty-seven patients were enrolled. The ARFI results showed high wave propagation velocity in 35 patients (94.6%). All patients had some abnormality in the hepatic MRI. Specifically, 8 patients (21.6%) showed signs of chronic liver disease, 10 patients (27%) had significant liver fibrosis, and 27 patients (73%) had congestion. No correlation was found between liver s...Continue Reading

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Citations

Mar 7, 2020·Journal of Cardiovascular Medicine·Gaetano D GargiuloGiuseppe Calcaterra
Feb 6, 2018·Seminars in Cardiothoracic and Vascular Anesthesia·Richard J Ing, Mark D Twite
Sep 29, 2020·Clinical Case Reports·Pier Paolo BassareoJohn Gerard Murray
Jul 15, 2020·Ultrasonography·İlhan HekimsoySüha Süreyya Özbek

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Methods Mentioned

BETA
biopsy
sedation
imaging technique
biopsies

Software Mentioned

SPSS

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