Noninvasive magnetic resonance imaging of transport and interstitial fluid pressure in ectopic human lung tumors

Cancer Research
Yaron HassidHadassa Degani

Abstract

Tumor response to blood borne drugs is critically dependent on the efficiency of vascular delivery and transcapillary transfer. However, increased tumor interstitial fluid pressure (IFP) forms a barrier to transcapillary transfer, leading to resistance to drug delivery. We present here a new, noninvasive method which estimates IFP and its spatial distribution in vivo using contrast-enhanced magnetic resonance imaging (MRI). This method was tested in ectopic human non-small-cell lung cancer which exhibited a high IFP of approximately 28 mm Hg and, for comparison, in orthotopic MCF7 human breast tumors which exhibited a lower IFP of approximately 14 mm Hg, both implanted in nude mice. The MRI protocol consisted of slow infusion of the contrast agent [gadolinium-diethylenetriaminepentaacetic acid (GdDTPA)] into the blood for approximately 2 hours, sequential acquisition of images before and during the infusion, and measurements of T1 relaxation rates before infusion and after blood and tumor GdDTPA concentration reached a steady state. Image analysis yielded parametric images of steady-state tissue GdDTPA concentration with high values of this concentration outside the tumor boundaries, approximately 1 mmol/L, declining in the tum...Continue Reading

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Citations

Jul 14, 2011·Annals of Biomedical Engineering·Gregory L PishkoMalisa Sarntinoranont
Nov 1, 2007·Bulletin of Experimental Biology and Medicine·A Yu LetyaginV I Ovcharenko
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Nov 1, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kristine GulliksrudEinar K Rofstad
Jul 22, 2008·Microvascular Research·Yaron HassidHadassa Degani
Jun 5, 2007·Trends in Molecular Medicine·Kristine GlundeZaver M Bhujwalla
Nov 23, 2007·International Journal of Cancer. Journal International Du Cancer·Simon P RobinsonArne Ostman
Nov 21, 2007·NMR in Biomedicine·Erez Eyal, Hadassa Degani
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Sep 18, 2012·Microvascular Research·Gregory L PishkoMalisa Sarntinoranont
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Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Terence P F GadeJason A Koutcher
Sep 4, 2014·Cancer Research·Jayashree Kalpathy-CramerBruce Rosen

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