Noninvasive mapping of electrical dyssynchrony in heart failure and cardiac resynchronization therapy

Cardiac Electrophysiology Clinics
Niraj VarmaPierre Bordachar

Abstract

Causes for diverse effects of cardiac resynchronization therapy (CRT) are poorly understood. Because CRT is an electrical therapy, it may be best understood by detailed characterization of electrical substrate and its interaction with pacing. Electrocardiogram (ECG) features affect CRT outcomes. However, the surface ECG reports rudimentary electrical data. In contrast, noninvasive electrocardiographic imaging provides high-resolution single-beat ventricular mapping. Several complex characteristics of electrical substrate, not decipherable from the 12-lead ECG, are linked to CRT effect. CRT response may be improved by candidate selection and left ventricular lead placement directed by more precise electrical evaluation, on an individual patient basis.

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Citations

Dec 7, 2019·Journal of Cardiovascular Electrophysiology·Niraj Varma
Oct 26, 2018·Circulation. Arrhythmia and Electrophysiology·John Rickard, Niraj Varma
Aug 3, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·David O'DonnellNiraj Varma
Oct 9, 2020·Circulation. Arrhythmia and Electrophysiology·Niraj VarmaRaffaele Corbisiero
May 10, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Niraj VarmaWojciech Zareba

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