Noninvasive markers for acute heart transplant rejection in children with the use of automatic border detection

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
T R KimballS R Daniels

Abstract

A noninvasive method to detect heart transplant rejection would allow for increased monitoring at reduced risk. Automatic border detection is a new method to assess diastolic abnormalities. The purpose of this study was to determine whether automatic border detection of left ventricular filling detects rejection in children. Nineteen episodes of biopsy-proven rejection in 10 children were retrospectively reviewed. Echocardiograms during rejection were compared with those before rejection and during recovery. Automatic border detection indices were percentage of total left ventricular filling as a result of rapid filling, diastasis, and atrial contraction. The percentage of total ventricular filling during diastasis increased significantly during rejection (10% +/- 6% versus 15% +/- 8%, p = 0.02), and the percentage of filling during the rapid filling phase decreased during rejection (82% +/- 8% versus 77% +/- 11%, p = 0.08). These changes were even more marked for the most severe episodes of rejection. These changes resolved at recovery. Automatic border detection of left ventricular filling patterns are altered during cardiac rejection in children. Filling during diastasis increases significantly, and filling during the rapid ...Continue Reading

References

Mar 1, 1991·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·R S Gibbons
Mar 1, 1995·American Heart Journal·A J Taylor, J D Bergin
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Citations

Sep 25, 2002·Transplantation Proceedings·J AlbersS Hagl
Dec 22, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G J PutzerR J Boucek
Feb 15, 2001·Echocardiography·Kirk T. SpencerRoberto M. Lang
Feb 15, 2001·Echocardiography·Thomas R. Kiall
Sep 15, 2000·Cardiology Clinics·M CourtoisS J Kovács
Jan 4, 2001·Current Opinion in Cardiology·J RussellR M Freedom

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