Noninvasive measurement of regional cerebral blood flow by near-infrared spectroscopy and indocyanine green

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
W M KueblerA E Goetz

Abstract

Clinicians lack a practical method for measuring CBF rapidly, repeatedly, and noninvasively at the bedside. A new noninvasive technique for estimation of cerebral hemodynamics by use of near-infrared spectroscopy (NIRS) and an intravenously infused tracer dye is proposed. Kinetics of the infrared tracer indocyanine green were monitored on the intact skull in pigs. According to an algorithm derived from fluorescein flowmetry, a relative blood flow index (BFI) was calculated. Data obtained were compared with cerebral and galeal blood flow values assessed by radioactive microspheres under baseline conditions and during hemorrhagic shock and resuscitation. Blood flow index correlated significantly (rs = 0.814, P < 0.001) with cortical blood flow but not with galeal blood flow (rs = 0.258). However, limits of agreement between BFI and CBF are rather wide (+/- 38.2 +/- 6.4 mL 100 g-1 min-1) and require further studies. Data presented demonstrate that detection of tracer kinetics in the cerebrovasculature by NIRS may serve as valuable tool for the noninvasive estimation of regional CBF. Indocyanine green dilution curves monitored noninvasively on the intact skull by NIRS reflect dye passage through the cerebral, not extracerebral, cir...Continue Reading

References

Aug 18, 1978·JAMA : the Journal of the American Medical Association·T R GarskiR A Finney
Apr 1, 1976·Journal of Applied Physiology·M L LandsmanW G Zijlstra
Feb 1, 1976·The American Journal of Physiology·M E RaichleM M Ter-Pogossian
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Feb 1, 1976·Biochemical Medicine·T J Muckle
Apr 1, 1975·Radiology·J M UszierW H Oldendorf
Apr 1, 1992·Journal of Cardiovascular Pharmacology·L J van WoerkensP D Verdouw
Dec 1, 1991·Anesthesia and Analgesia·D S ProughD S DeWitt
Feb 1, 1992·Journal of Neurosurgery·P W McCormickJ I Ausman
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H YonasC Maxwell
May 1, 1991·Stroke; a Journal of Cerebral Circulation·P W McCormickG Balakrishnan
Oct 1, 1990·Computer Methods and Programs in Biomedicine·W GrossK Messmer
Aug 1, 1989·Catheterization and Cardiovascular Diagnosis·R BenyaB Brundage
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A LassenO B Paulson
Dec 1, 1988·Physics in Medicine and Biology·D T DelpyJ Wyatt
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B ChanceM Young
Aug 15, 1988·Annals of Internal Medicine·V GarriguesJ Berenguer
Aug 15, 1988·Annals of Internal Medicine·R SpeichJ Reichen
Mar 1, 1987·Journal of the Optical Society of America. A, Optics and Image Science·R F BonnerG H Weiss
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Jan 1, 1969·Journal of Applied Physiology·K Kogure, E Choromokos
Jan 1, 1981·Neurological Research·J M ColacinoF F Jöbsis
May 1, 1995·Journal of Neurosurgery·P J KirkpatrickJ D Pickard
Jan 1, 1994·Advances in Experimental Medicine and Biology·D N HarrisD A Wertheim
Aug 1, 1993·Journal of Applied Physiology·M O Den BoerP D Verdouw
Jan 1, 1993·Life Sciences·M HallerK Peter

❮ Previous
Next ❯

Citations

Feb 15, 2005·Ultrasound in Medicine & Biology·Johan M Thijssen, Chris L de Korte
Jun 27, 2002·Journal of Neuroscience Methods·Emanuela KellerKarl Frei
Aug 7, 2003·Neuroscience Letters·W M KueblerB Zwissler
Jun 14, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Geofrey De VisscherRobert S Reneman
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Rickson C MesquitaArjun G Yodh
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Hellmuth Obrig, Jens Steinbrink
Feb 25, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H W SchytzM Ashina
May 29, 2010·Journal of Applied Physiology·Dimitris AthanasopoulosIoannis Vogiatzis
Mar 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Berthold BeinVolker Doerges
Jan 6, 2010·International Journal of Pediatrics·David T Mage, Maria Donner
Apr 24, 2012·Respiratory Physiology & Neurobiology·William R HendersonA William Sheel
Jan 25, 2011·Brain Research Bulletin·Ujwal ChaudharyAnuradha Godavarty
Jun 29, 2010·Seminars in Fetal & Neonatal Medicine·Adelina Pellicer, María del Carmen Bravo
Nov 4, 2015·Respiratory Physiology & Neurobiology·Mayron F OliveiraJ Alberto Neder
Apr 3, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hye-Min KangChan Park
Oct 16, 2015·Neurobiology of Aging·Hye-Min KangChan Park
Oct 25, 2006·The Journal of Thoracic and Cardiovascular Surgery·Jens SteinbrinkWolfgang M Kuebler
Jul 18, 2003·Neurological Research·Ralf Dirk RothoerlAlexander Brawanski
Aug 8, 2009·Neurological Research·Mateo Calderon-ArnulphiKonstantin V Slavin
Sep 5, 2003·Physics in Medicine and Biology·D A BoasJ B Mandeville
Aug 26, 2017·Experimental Physiology·Paolo B DominelliA William Sheel
Apr 12, 2000·Acta Physiologica Scandinavica·R Boushel, C A Piantadosi
Nov 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ichiro NakagawaHiroyuki Nakase
Jul 31, 2007·Muscle & Nerve·Edwin R MulderArnold de Haan
Apr 29, 2006·Stroke; a Journal of Cerebral Circulation·Johannes WoitzikClaudius Thomé

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

MIC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.