Noninvasive measurement of the maximum relaxation rate of inspiratory muscles in patients with neuromuscular disorders

Respiration; International Review of Thoracic Diseases
Francisco García-RíoJosé Villamor

Abstract

Slowing of inspiratory muscle relaxation has been used as an index for inspiratory muscle fatigue. However, maximum relaxation rate measured from oesophageal pressure traces after maximum sniff (P(oes) MRR) has limited clinical usefulness because it requires an oesophageal balloon catheter system. It was the aim of this study to establish whether, in neuromuscular patients, maximum relaxation rate assessed from sniff nasal pressure (P(nasal) MRR) reflects oesophageal MRR and the tension-time index of the diaphragm (TT(di)). Twenty patients with neuromuscular disease and 10 healthy subjects were studied. P(oes) and transdiaphragmatic pressure were measured while P(nasal) was recorded with a balloon advanced through the nose into the nasopharynx. Maximum P(oes), transdiaphragmatic pressure and P(nasal) were simultaneously measured while the patients performed maximal sniffs. The MRR (% pressure fall/10 ms) for each sniff, the TT(di) and the tension-time index of respiratory muscles were determined. Neuromuscular patients showed higher TT(di), lower P(oes) MRR and lower P(nasal) MRR than the control group. In patients with neuromuscular disease, the correlation coefficient of P(nasal) MRR and P(oes) MRR was 0.985 (p < 0.001). Regr...Continue Reading

References

May 1, 1990·Journal of Applied Physiology·T E Dick, E van Lunteren
Mar 1, 1989·The American Review of Respiratory Disease·N KoulourisJ Moxham
Sep 1, 1988·The American Review of Respiratory Disease·D F Rochester
Oct 25, 1986·British Medical Journal·S T ChanH A Dudley
Aug 1, 1988·The American Review of Respiratory Disease·C M LarocheM Green
Sep 1, 1988·The American Review of Respiratory Disease·C M LarocheM Green
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S A EsauR L Pardy
May 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S A EsauR L Pardy
Nov 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F Bellemare, A Grassino
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·F HéritierJ W Fitting
Jun 1, 1997·The European Respiratory Journal·C UldryJ W Fitting
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·D StefanuttiJ W Fitting
Jun 17, 2003·Journal of Applied Physiology·Francisco García-RíoJosé Villamor
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

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Citations

Apr 9, 2019·The European Respiratory Journal·Pierantonio LavenezianaSamuel Verges
Jun 9, 2017·PloS One·Morgana de Araújo EvangelistaGuilherme Augusto de Freitas Fregonezi

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