Noninvasive method for measurement of cerebral blood flow using O-15 water PET/MRI with ASL correlation

European Journal of Radiology
Hidehiko OkazawaKen-Ichiro Kikuta

Abstract

A noninvasive image derived input function (IDIF) method was applied to estimate arterial input function from brain H215O-PET/MRI images for the measurement of cerebral blood flow (CBF) because of difficulty in arterial blood sampling during PET/MRI scans. To evaluate accuracy and reproducibility of radioactivity in the internal carotid arteries (ICA) for the IDIF method, a new phantom using a skull bone was applied in the cross-calibration process between the scanner and a gamma-well counter. Eleven healthy volunteers (9 males, 43.9 ± 10.9y) underwent PET/MRI studies with a 3-min H215O-PET and several MRI scans including arterial spin labeling (ASL) perfusion MRI. PET images were reconstructed as dynamic data using two sets of reconstruction parameters, which were determined by basic assessment of radioactivity concentration reproducibility in the tubes of the phantom. The IDIF method extracted the time-activity curves of the ICA from several image slices in the PET data. CBF images were calculated using the autoradiographic (ARG) method and a one-tissue compartment model (1-TCM). The global means of CBF from the ARG, 1-TCM, and ASL-MRI were 44.8 ± 4.3, 47.9 ± 5.9 and 57.9 ± 8.6 (mL/min/100 g), respectively. CBF from ASL-MRI w...Continue Reading

Citations

Jun 11, 2020·Current Opinion in Neurology·Nadya PyatigorskayaLaura Rozenblum
Sep 11, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Oriol PuigIan Law
Aug 17, 2019·Frontiers in Neuroscience·Yuankai Zhu, Xiaohua Zhu
Jul 14, 2020·Current Opinion in Neurology·Nadya PyatigorskayaLaura Rozenblum
Aug 29, 2020·Diagnostics·Yurii ShepelytskyiMitchell S Albert
Dec 2, 2020·Diagnostics·Hidehiko OkazawaHirotaka Kosaka
Feb 10, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Samuel KuttnerJan Axelsson
Apr 20, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Hiroyuki Kabasawa
Aug 27, 2021·EJNMMI Physics·Eve LennieSteven Sourbron

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