Noninvasive method for the detection of bowel ischemia: computed tomography detection of absorbed iodinated contrast material

Academic Radiology
M D LinkousH I Goldberg

Abstract

Although systemic absorption of enterically administered iohexol and its excretion in urine has been previously documented in rats with ischemic bowel, a practical and sensitive method of detecting urinary iohexol has not been available. We proposed to detect the presence of iohexol in the urine of rats with normal and ischemic bowel by use of a computed tomography (CT) number increase in the bladder with the use of CT. Anesthetized rats (250 g) underwent either sham laparotomy (n = 6), ligation of two vascular arcades to the proximal jejunum (n = 5), ligation of six vascular arcades to the proximal jejunum (n = 6), or ligation of the superior mesenteric artery (n = 6). Rats were hydrated with saline (3.2 ml/hr intravenously). Each received a 3-ml enteric bolus of isotonic iohexol. Serial CT scans and plain film radiographs of the bladder were performed at 2, 4, and 6 hr to detect systemic absorption of contrast from the gut. Urine iohexol concentrations were measured by capillary electrophoresis. CT number and iohexol concentration were compared with evidence from plain film radiographs of bladder opacification. Intestinal ischemia was graded histologically. Histologic evidence of ischemia was present in all six-arcade and fiv...Continue Reading

References

Jan 1, 1990·AJR. American Journal of Roentgenology·M J SmerudD H Stephens
Jun 1, 1986·Journal of Pediatric Surgery·D J SchwartzentruberJ L Grosfeld
Jul 1, 1962·Archives of Surgery·W SILENL GOLDMAN

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